Evidence map›Paper›PMID 41280005›Full record

ArticlebioRxiv : the preprint server for biology2025

Nuclear receptor-neurotransmitter coupling links behavior to metabolic state.

Porhathai Malaiwong, Allen F Schroeder, Tia Brown, Chester J Wrobel, Madhumanti Dasgupta, Nawaphat Malaiwong, Frank C Schroeder, Michael P O'Donnell

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Porhathai MalaiwongDept. of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06511.
Allen F SchroederBoyce Thompson Institute and Dept. of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853.
Tia BrownDept. of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06511.
Chester J WrobelBoyce Thompson Institute and Dept. of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853.
Madhumanti DasguptaDept. of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06511.
Nawaphat MalaiwongDept. of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06511.
Frank C SchroederBoyce Thompson Institute and Dept. of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853.
Michael P O'DonnellDept. of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06511.ORCID 0000-0001-8313-8969

Funding

Small molecule signaling in C. elegansR35GM131877 · NIGMS · BOYCE THOMPSON INST FOR PLANT RESEARCH · PI Frank Clemens Schroeder · 2019 to 2026
$5.0M
Molecular determinants of host-feeding manipulation and microbial colonizationDP2GM154014 · NIGMS · YALE UNIVERSITY · PI Michael Patrick ODonnell · 2023 to 2026
$2.3M
NIGMS NIH HHS DP2 GM154014NIGMS NIH HHS R35 GM131877
6 · The paper itself

Abstract

Animals must flexibly respond to environmental stimuli to survive, and optimal responses critically depend on the organism's current needs. Many organisms have evolved both cell-intrinsic and intertissue signaling pathways that integrate metabolic status. However, how this information is encoded in molecular signals is currently not well understood. Here we show that the nematode

Identifiers

PMID41280005
PMCPMC12633440

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.