ArticlebioRxiv : the preprint server for biology2025
SpaDiff: Denoising for Sequence-based Spatial Transcriptomics via Diffusion Process.
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
Spatial transcriptomics enables transcriptome-scale analysis with spatial resolution but suffers from spot-swapping, where RNA molecules drift from their true locations, introducing noise and reducing spatial specificity. We introduce SpaDiff, a denoising method that treats spot-swapping as a diffusion process. SpaDiff simulates the displacement of RNA molecules and reverses it to restore their original spatial distribution while preserving molecular counts. Evaluations on simulated and real data demonstrate that SpaDiff enhances spatial specificity of gene expression, improves data integrity, and supports more accurate downstream analyses such as clustering and spatial domain identification.
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