Evidence map›Paper›PMID 41279974›Full record

ArticlebioRxiv : the preprint server for biology2025

Mapping Structural Constraints and Adaptive Potential in a Capsule-Degrading Phage Tailspike Protein.

Sarah Evert, Phill Huss, Dinesh Kumar Kuppa Baskaran, Karthik Anantharaman, Srivatsan Raman

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Sarah EvertDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA.ORCID 0009-0000-5559-4748
Phill HussDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA.ORCID 0000-0003-4064-9333
Dinesh Kumar Kuppa BaskaranDepartment of Bacteriology, University of Wisconsin-Madison, Madison, WI, USA.
Karthik AnantharamanDepartment of Bacteriology, University of Wisconsin-Madison, Madison, WI, USA.ORCID 0000-0002-9584-2491
Srivatsan RamanDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA.ORCID 0000-0002-5673-6944

Funding

COMPUTATIONAL FRAMEWORKS FOR PHAGE DISCOVERY, ECOLOGY, AND DYNAMICS FROM METAGENOMESR35GM143024 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI ANANTHARAMAN, KARTHIK · 2021 to 2025
$1.9M
NIGMS NIH HHS R35 GM143024
6 · The paper itself

Abstract

Bacteriophage tailspike proteins (TSPs) degrade bacterial capsules to enable infection, yet the molecular determinants of their function and host range remain unclear. We applied deep mutational scanning (DMS) to the endosialidase TSP of

Identifiers

PMID41279974
PMCPMC12632334

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.