Evidence map›Paper›PMID 41279952›Full record

ArticlebioRxiv : the preprint server for biology2025

A newly designed GABA-AT inactivator, (

Luana Assis Ferreira, Koon Mook Kang, Ifeoluwa Solomon, Richard B Silverman, Andrea G Hohmann

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Luana Assis FerreiraDepartment of Psychological and Brain Sciences, Indiana University, Bloomington, IN 47405.ORCID 0000-0001-6346-269X
Koon Mook KangDepartment of Chemistry, Northwestern University, Evanston, IL 60208.ORCID 0000-0001-9336-840X
Ifeoluwa SolomonDepartment of Psychological and Brain Sciences, Indiana University, Bloomington, IN 47405.ORCID 0009-0007-2324-3856
Richard B SilvermanDepartment of Chemistry, Northwestern University, Evanston, IL 60208.ORCID 0000-0001-9034-1084
Andrea G HohmannDepartment of Psychological and Brain Sciences, Indiana University, Bloomington, IN 47405.ORCID 0000-0003-0941-6435

Funding

New Inactivators of GABA Aminotransferase for Addiction and EpilepsyR01DA030604 · NIDA · NORTHWESTERN UNIVERSITY · PI SILVERMAN, RICHARD B · 2011 to 2020
$4.0M
CB2 Cannabinoid Mechanisms for Suppressing Opioid Tolerance and DependenceR01DA047858 · NIDA · TRUSTEES OF INDIANA UNIVERSITY · PI HOHMANN, ANDREA GRACE, MACKIE, KENNETH · 2019 to 2023
$2.6M
New Inactivators of GABA Aminotransferase for Epilepsy and Neuropathic PainR01NS123057 · NINDS · NORTHWESTERN UNIVERSITY · PI SILVERMAN, RICHARD B · 2021 to 2025
$2.5M
NIDA NIH HHS R01 DA030604NIDA NIH HHS R01 DA047858NINDS NIH HHS R01 NS123057
6 · The paper itself

Abstract

Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a common and debilitating side effect of paclitaxel treatment. Pharmacological strategies that enhance inhibitory tone, via inhibition of γ-aminobutyric acid aminotransferase (GABA-AT), the enzyme which degrades endogenous GABA, provides analgesic benefit in preclinical studies. ( Methods: Results: In MTT assays, ( Conclusion: (

Indexed as

Chemotherapy-induced peripheral neuropathyGABA-aminotransferase inhibitionneuropathic painpaclitaxel(S)-MeCPP-115

Identifiers

PMID41279952
PMCPMC12633538

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.