ArticlebioRxiv : the preprint server for biology2025
Roles of G-protein coupled receptors and mechanosensitive ion channels in pressure-induced chronotropy of lymphatic vessels.
Michael J Davis, Hae Jin Kim, Min Li, Jorge A Castorena-Gonzalez, Soumiya Pal, Timothy L Domeier, Joshua P Scallan, Scott Earley, Scott D Zawieja
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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5 · Who and what moneyAuthors and funding
9 authors.
Hae Jin KimDept. of Medical Pharmacology & Physiology, University of Missouri, Columbia MO.
Min LiDept. of Medical Pharmacology & Physiology, University of Missouri, Columbia MO.
Jorge A Castorena-GonzalezDept. of Pharmacology, Tulane University School of Medicine, New Orleans LA.
Soumiya PalDept. of Medical Pharmacology & Physiology, University of Missouri, Columbia MO.
Timothy L DomeierDept. of Medical Pharmacology & Physiology, University of Missouri, Columbia MO.
Joshua P ScallanDept. of Molecular Pharmacology & Physiology, University of South Florida, Morisani School of Medicine, Tampa FL.
Scott EarleyDepartment of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY.
Scott D ZawiejaDept. of Medical Pharmacology & Physiology, University of Missouri, Columbia MO.
Funding
TRP channels as fundamental sensors of the cerebral microcirculationR35HL155008 · NHLBI · UNIVERSITY OF ROCHESTER · PI Scott Earley · 2021 to 2026
$5.5MLymphatic pacemaking and pumping in lymphedema: function, dysfunction, and rescueR01HL122578 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI DAVIS, MICHAEL JOHN · 2015 to 2023
$4.1MCardiomyocyte TRPV4 and cardiac dysfunction following ischemia-reperfusion in the aged heart.R01HL136292 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI Timothy Lee Domeier · 2017 to 2026
$3.5MPathways Regulating Lymphatic Vessel Permeability and Valve FormationR01HL142905 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI SCALLAN, JOSHUA PAUL · 2019 to 2023
$2.2MTrpv4 regulation of lymphatic vascular function: Implications in metabolic syndromeR01HL168568 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI Jorge Augusto Castorena · 2023 to 2026
$1.9MRegulation of lymphatic muscle cell function by store operated calcium entry signalingR01HL175083 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI Scott D. Zawieja · 2024 to 2026
$1.7MThe Regulation of Lymphatic Muscle Cell Pacemaking by Intracellular Calcium SignalsR00HL143198 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI ZAWIEJA, SCOTT D. · 2021 to 2023
$747kThe Regulation of Lymphatic Muscle Cell Pacemaking by Intracellular Calcium SignalsK99HL143198 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI ZAWIEJA, SCOTT D. · 2019 to 2020
$203kNHLBI NIH HHS K99 HL143198NHLBI NIH HHS R00 HL143198NHLBI NIH HHS R01 HL122578NHLBI NIH HHS R01 HL136292NHLBI NIH HHS R01 HL142905NHLBI NIH HHS R01 HL168568NHLBI NIH HHS R01 HL175083NHLBI NIH HHS R35 HL155008
6 · The paper itselfAbstract
Active lymph pumping relies on the spontaneous contractions of collecting lymphatic vessels, with frequencies that are exquisitely sensitive to changes in intraluminal pressure. This homeostatic and mechanosensitive mechanism, termed pressure-induced lymphatic chronotropy, enables lymph transport to be matched to the filling state of the lymphatic capillaries. We investigated the mechanistic basis of pressure-induced chronotropy using ex vivo contraction assays of mouse popliteal collecting vessels, in which contraction frequency increased >10-fold with a 5 cmH
Indexed as
ANO1G proteinsmechanotransductionPIEZO1TRP channels
Identifiers
PMID41279936
PMCPMC12632312
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