Evidence map›Paper›PMID 41279925›Full record

ArticlebioRxiv : the preprint server for biology2025

The scaffold protein PRR14L links the PP2A-TACC3 axis to mitotic fidelity and sensitivity to MPS1 inhibition.

Albert Z Liu, Akshay Narkar, Keming Li, Thierry Bertomeu, Blake A Johnson, Jasmin Coulombe-Huntington, Yi Dong, Jin Zhu, Mike Tyers, Rong Li

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Albert Z LiuDepartment of Cell Biology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0002-9387-0878
Akshay NarkarDepartment of Cell Biology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0002-3649-1230
Keming LiMechanobiology Institute, National University of Singapore, Singapore 117411, Singapore.ORCID 0009-0008-4174-8855
Thierry BertomeuThe ChemoGenix CRISPR screening facility of the Institute for Research in Immunology and Cancer, University of Montreal, 2950 Chemin de Polytechnique, Montréal, QC H3T 1J4, Canada.ORCID 0000-0002-5313-7057
Blake A JohnsonDepartment of Cell Biology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0001-7830-2453
Jasmin Coulombe-HuntingtonDepartment of Bioengineering, McGill University, Montreal, QC H3A 0E9, Canada.ORCID 0000-0003-0292-7654
Yi DongDepartment of Cell Biology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0002-9802-4953
Jin ZhuMechanobiology Institute, National University of Singapore, Singapore 117411, Singapore.
Mike TyersDepartment of Molecular Genetics, University of Toronto; Toronto, Ontario M5S 1A8, Canada.ORCID 0000-0002-9713-9994
Rong LiDepartment of Cell Biology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0002-0540-6566

Funding

BioGRID: An open resource for biological interactions and network analysisR01OD010929 · OD · SINAI HEALTH SYSTEM · PI KARA DOLINSKI, Mike Tyers · 2012 to 2026
$13.9M
Medical Scientist Training ProgramT32GM136577 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI ANDREA L COX · 2020 to 2026
$13.4M
NIGMS NIH HHS T32 GM136577NIH HHS R01 OD010929
6 · The paper itself

Abstract

Aneuploidy is a hallmark of cancer and is a potential vulnerability that can be selectively targeted. To systematically identify genes that affect the incidence and fitness of aneuploid cells, we conducted a genome-wide CRISPR/Cas9 screen using NMS-P715, an inhibitor of the spindle assembly checkpoint (SAC) kinase MPS1/TTK. In this study, we identified a number of genes known to regulate aneuploidy and mitosis, and subsequently focused on

Identifiers

PMID41279925
PMCPMC12637489

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.