Evidence map›Paper›PMID 41279917›Full record

ArticlebioRxiv : the preprint server for biology2025

Incorporation of microbially salvaged urea-nitrogen into anabolic amino acids during hibernation in arctic ground squirrels.

Sarah A Rice, Kirsten Grond, Sarah M Gering, Julie A Reisz, Taylor R M Bailey-Parsons, C Loren Buck, Khrystyne N Duddleston

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Sarah A RiceInstitute of Arctic Biology, University of Alaska Fairbanks.
Kirsten GrondDepartment of Biological Sciences, University of Alaska Anchorage.
Sarah M GeringDepartment of Biological Sciences, University of Alaska Anchorage.
Julie A ReiszDepartment of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus.
Taylor R M Bailey-ParsonsDepartment of Biological Sciences, University of Alaska Anchorage.
C Loren BuckDepartment of Biological Sciences, Northern Arizona University.
Khrystyne N DuddlestonDepartment of Biological Sciences, University of Alaska Anchorage.

Funding

Renovation of LARS for Arctic Ground Squirrel BreedingP20GM130443 · NIGMS · UNIVERSITY OF ALASKA FAIRBANKS · PI Kriya L Dunlap · 2019 to 2026
$16.4M
Beneficial ureolytic microbes and urea nitrogen salvage: examinations in an extreme animal modelR15DK110784 · NIDDK · UNIVERSITY OF ALASKA ANCHORAGE · PI DUDDLESTON, KHRYSTYNE · 2016 to 2016
$454k
NIDDK NIH HHS R15 DK110784NIGMS NIH HHS P20 GM130443
6 · The paper itself

Abstract

Hibernators rely on endogenous supplies of amino acids (AAs) and other nutrients to sustain organ function and skeletal muscle mass. Gut microbiota-mediated recycling of urea-nitrogen into AAs has long been considered a mechanism to assist in conserving nitrogen; however, the relevance of urea nitrogen salvage (UNS) to overall host physiology and metabolism is debated. We hypothesized that incorporation of microbially-liberated urea-nitrogen (MLUN) into AAs would be higher in host tissues of hibernating arctic ground squirrels compared to those of summer active squirrels, and that MLUN would support synthesis of anabolic AAs that regulate protein balance. To test this, we injected [

Indexed as

arctic ground squirrelfluxomicshibernationmetabolismmicrobial urea nitrogen salvagestable isotope tracer

Identifiers

PMID41279917
PMCPMC12632882

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.