Evidence map›Paper›PMID 41279890›Full record

ArticlebioRxiv : the preprint server for biology2025

NF-κB-Dependent Transcriptional Regulation of Piezo1 Mediates Bacterial Clearance on Stiffened Lung Matrix.

Erica M Orsini, Adam M Boulton, Susamma Abraham, Alyson Brown, Haley Ricci, Akash Ahuja, Bishnu Pant, Caitlin M Snyder, Amanda Reinhardt, Amy H Attaway and 5 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Erica M OrsiniIntegrated Hospital Care Institute, Cleveland Clinic, Cleveland, OH.ORCID 0000-0003-2805-4783
Adam M BoultonInflammation and Immunity, Cleveland Clinic Research, Cleveland Clinic, Cleveland, OH.
Susamma AbrahamInflammation and Immunity, Cleveland Clinic Research, Cleveland Clinic, Cleveland, OH.
Alyson BrownCleveland Clinic Lerner College of Medicine, Cleveland, OH.
Haley RicciInflammation and Immunity, Cleveland Clinic Research, Cleveland Clinic, Cleveland, OH.
Akash AhujaInflammation and Immunity, Cleveland Clinic Research, Cleveland Clinic, Cleveland, OH.
Bishnu PantInflammation and Immunity, Cleveland Clinic Research, Cleveland Clinic, Cleveland, OH.
Caitlin M SnyderInflammation and Immunity, Cleveland Clinic Research, Cleveland Clinic, Cleveland, OH.
Amanda ReinhardtInflammation and Immunity, Cleveland Clinic Research, Cleveland Clinic, Cleveland, OH.
Amy H AttawayIntegrated Hospital Care Institute, Cleveland Clinic, Cleveland, OH.
Ryan MusichInflammation and Immunity, Cleveland Clinic Research, Cleveland Clinic, Cleveland, OH.
Lisa M GroveInflammation and Immunity, Cleveland Clinic Research, Cleveland Clinic, Cleveland, OH.
Mitchell A OlmanIntegrated Hospital Care Institute, Cleveland Clinic, Cleveland, OH.
Vidula VachharajaniIntegrated Hospital Care Institute, Cleveland Clinic, Cleveland, OH.
Rachel G ScheragaIntegrated Hospital Care Institute, Cleveland Clinic, Cleveland, OH.ORCID 0000-0001-5113-543X

Funding

TRPV4 Regulates Mechanosensitive Macrophage Functions in Lung InjuryR01HL155064 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI SCHERAGA, RACHEL GREENBERG · 2021 to 2025
$2.1M
Supporting Multidisciplinary Achievement in Respiratory Research Training (SMARRT)T32HL155005 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI Raed A. Dweik · 2021 to 2026
$1.9M
Profibrotic Mechanisms of the TRPV4-PI3K-gamma Protein ComplexR01HL158746 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI OLMAN, MITCHELL ALAN · 2021 to 2024
$1.6M
Immune Function in Sepsis: Role of SirtuinR35GM149240 · NIGMS · CLEVELAND CLINIC LERNER COM-CWRU · PI Vidula Vachharajani · 2023 to 2026
$1.6M
NHLBI NIH HHS R01 HL155064NHLBI NIH HHS R01 HL158746NHLBI NIH HHS T32 HL155005NIGMS NIH HHS R35 GM149240
6 · The paper itself

Abstract

Respiratory pathogens, such as

Identifiers

PMID41279890
PMCPMC12637684

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.