Evidence map›Paper›PMID 41279874›Full record

ArticlebioRxiv : the preprint server for biology2025

A default silencing mechanism restrains stress-induced genes in

Orkan Ilbay, Alejandro Rodriguez Gama, Daniel F Jarosz, Richard I Morimoto, Andrew Fire

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Orkan IlbayStanford University, Department of Pathology, Stanford, CA, USA.ORCID 0000-0002-7963-5054
Alejandro Rodriguez GamaDepartment of Molecular Biosciences, Northwestern University, Evanston, Illinois 60208, USA.
Daniel F JaroszDepartment of Chemical & Systems Biology, Stanford University School of Medicine, Stanford, CA, USA.
Richard I MorimotoDepartment of Molecular Biosciences, Northwestern University, Evanston, Illinois 60208, USA.
Andrew FireStanford University, Department of Pathology, Stanford, CA, USA.

Funding

Tissue resident macrophages regulate proteostasis in the aging lungP01AG049665 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GR Scott Budinger · 2015 to 2026
$26.9M
Cellular Response to Genetic ChangeR35GM130366 · NIGMS · STANFORD UNIVERSITY · PI ANDREW Z. FIRE · 2019 to 2026
$4.8M
Investigating protein phase separation and aggregation in age dependent human diseaseR01AG086495 · NIA · STANFORD UNIVERSITY · PI Daniel Jarosz · 2024 to 2026
$3.6M
Evaluating the role of protein self-assembly in the innate immune systemK00AG068511 · NIA · NORTHWESTERN UNIVERSITY · PI Alejandro Rodriguez Gama · 2023 to 2026
$342k
A robotic plate handling system for high content screening and 3D organoid cultureS10OD032367 · OD · NORTHWESTERN UNIVERSITY · PI HORVATH, CURT M · 2022 to 2022
$137k
NIA NIH HHS K00 AG068511NIA NIH HHS P01 AG049665NIA NIH HHS R01 AG086495NIGMS NIH HHS R35 GM130366NIH HHS S10 OD032367
6 · The paper itself

Abstract

Inducible gene expression programs require that target genes remain silent until the proper activation signal is received, a hallmark of stress-response pathways. This quiescence is typically assumed to be the default state of stress-inducible genes, maintained without active cellular intervention. Using a forward genetic screen for constitutive activation of inducible heat shock proteins (iHSPs) in

Identifiers

PMID41279874
PMCPMC12633554

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.