Evidence map›Paper›PMID 41279871›Full record

ArticlebioRxiv : the preprint server for biology2025

Adipocytes are dispensable in shaping the ovarian cancer tumor microenvironment in the omentum.

Rachel L Mintz, Jichang Han, Emily G Butka, Alexandre Gallerand, Ayoung Kim, Sarah Ning, Nicole K H Yiew, Mary Wohltmann, Wei Zou, Nan Zhang and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Rachel L MintzDepartment of Biomedical Engineering, Washington University, St. Louis, Missouri, USA.
Jichang HanDepartment of Pathology and Immunology, Washington University, St. Louis, Missouri, USA.
Emily G ButkaVagelos Division of Biomedical and Biological Sciences, Washington University, St. Louis, Missouri, USA.
Alexandre GallerandDepartment of Pathology and Immunology, Washington University, St. Louis, Missouri, USA.
Ayoung KimDepartment of Pathology and Immunology, Washington University, St. Louis, Missouri, USA.
Sarah NingDepartment of Pathology and Immunology, Washington University, St. Louis, Missouri, USA.
Nicole K H YiewDepartment of Pathology and Immunology, Washington University, St. Louis, Missouri, USA.
Mary WohltmannDepartment of Pathology and Immunology, Washington University, St. Louis, Missouri, USA.
Wei ZouDepartment of Pathology and Immunology, Washington University, St. Louis, Missouri, USA.ORCID 0000-0002-3127-1343
Nan ZhangImmunology, Microenvironment and Metastasis Program, Ellen and Ronald Caplan Cancer Center, The Wistar Institute, Philadelphia, PA, USA.
Samantha A MorrisDepartment of Genetics and Developmental Biology, Washington University, St. Louis, Missouri, USA.
Bernd H ZinselmeyerDepartment of Pathology and Immunology, Washington University, St. Louis, Missouri, USA.
Gwendalyn J RandolphDepartment of Pathology and Immunology, Washington University, St. Louis, Missouri, USA.ORCID 0000-0001-9045-1195

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI Shawn Shafer · 2001 to 2026
$128.0M
DIFFERENTIATION AND FUNCTION OF MONOCYTES AND MACROPHAGESR37AI049653 · NIAID · WASHINGTON UNIVERSITY · PI RANDOLPH, GWENDALYN J · 2016 to 2025
$4.3M
Hepatic steatosis promotes liver metastasisR01CA258325 · NCI · WASHINGTON UNIVERSITY · PI Nidhi Rohatgi · 2022 to 2026
$2.3M
IVIS Spectrum CT Preclinical In Vivo Imaging SystemS10OD027042 · OD · WASHINGTON UNIVERSITY · PI ACHILEFU, SAMUEL · 2019 to 2019
$599k
Deciphering the role of tumor-macrophage crosstalk during metastatic dissemination to the peritoneumK00CA264434 · NCI · WASHINGTON UNIVERSITY · PI HAN, JICHANG · 2022 to 2025
$388k
Dynamics and function of peritoneal myeloid cells during colorectal cancer peritoneal dissemination and implications for immunotherapyK99CA300889 · NCI · WASHINGTON UNIVERSITY · PI Jichang Han · 2025 to 2026
$334k
NCI NIH HHS K00 CA264434NCI NIH HHS K99 CA300889NCI NIH HHS P30 CA091842NCI NIH HHS R01 CA258325NIAID NIH HHS R37 AI049653NIH HHS S10 OD027042
6 · The paper itself

Abstract

The omentum, a specialized adipose tissue within the peritoneum, is a primary niche for ovarian cancer (OC) dissemination during peritoneal carcinomatosis. Traditionally, omental adipocytes are thought to promote OC growth by supplying lipids, supported by evidence that global FABP4 deficiency reduces tumor progression. Here, we generated mice lacking mature adipocytes in the peritoneum, including the omentum. ID8p53

Identifiers

PMID41279871
PMCPMC12636596

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.