Evidence map›Paper›PMID 41279844›Full record

ArticlebioRxiv : the preprint server for biology2025

mRNA 3' UTRs direct microRNA degradation to participate in imprinted gene networks and regulate growth.

Daniel H Lin, Lara E Elcavage, Ekaterina Khalizeva, David P Bartel

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Daniel H LinWhitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.ORCID 0000-0002-1393-3374
Lara E ElcavageWhitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.ORCID 0000-0003-1457-2109
Ekaterina KhalizevaWhitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.ORCID 0009-0003-1060-0835
David P BartelWhitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.ORCID 0000-0002-3872-2856

Funding

Medical Scientist Training ProgramT32GM007753 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WALENSKY, LOREN DAVID · 1985 to 2021
$50.0M
Medical Scientist Training ProgramT32GM144273 · NIGMS · HARVARD MEDICAL SCHOOL · PI David Shumway Jones, Jacqueline A. Lees · 2022 to 2026
$14.7M
Post-transcriptional gene regulationR35GM118135 · NIGMS · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI DAVID P BARTEL · 2016 to 2026
$10.7M
Pre-doctoral Training in Fundamental Approaches to Biochemistry and Cell and Molecular BiologyT32GM136540 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Mary Gehring, Michael Laub · 2021 to 2026
$9.5M
Characterization of the role of ZSWIM8 and target-directed microRNA degradation in hematopoiesisF30HL175923 · NHLBI · HARVARD MEDICAL SCHOOL · PI Lara Elcavage · 2024 to 2026
$164k
NHLBI NIH HHS F30 HL175923NIGMS NIH HHS R35 GM118135NIGMS NIH HHS T32 GM007753NIGMS NIH HHS T32 GM136540NIGMS NIH HHS T32 GM144273
6 · The paper itself

Abstract

MicroRNAs direct downregulation of target mRNAs. Sometimes, however, this regulatory paradigm inverts, and a target RNA triggers the degradation of a microRNA. This target-directed microRNA degradation (TDMD) requires ZSWIM8.

Identifiers

PMID41279844
PMCPMC12637508

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.