Evidence map›Paper›PMID 41279834›Full record

ArticlebioRxiv : the preprint server for biology2025

Integrating Mathematical and Mouse Models Identifies T Regulatory Cell Influx as A Key Determinant of Acquired Resistance to PD-1 Immunotherapy.

Rachel S Sousa, Shannon N Geels, Claire Murat, Alexander Moshensky, S Armando Villalta, John S Lowengrub, Francesco Marangoni

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Rachel S SousaCenter for Complex Biological Systems, University of California Irvine, Irvine CA.
Shannon N GeelsInstitute for Immunology, University of California Irvine, Irvine CA.
Claire MuratInstitute for Immunology, University of California Irvine, Irvine CA.
Alexander MoshenskyInstitute for Immunology, University of California Irvine, Irvine CA.
S Armando VillaltaInstitute for Immunology, University of California Irvine, Irvine CA.
John S LowengrubCenter for Complex Biological Systems, University of California Irvine, Irvine CA.
Francesco MarangoniInstitute for Immunology, University of California Irvine, Irvine CA.ORCID 0000-0002-2490-849X

Funding

Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Melanie Funes · 1994 to 2026
$57.9M
Understanding critical transitions in chronic myeloid leukemia to improve tyrosine kinase inhibitor therapyP01CA288662 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI John Lowengrub · 2025 to 2026
$6.4M
UCI P30 Skin Center Systems Biology CoreP30AR075047 · NIAMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI ANDERSEN, BOGI, GANESAN, ANAND K · 2019 to 2025
$5.1M
Novel macrophage and regulatory T cell interactions that promote the pathogenesis of Duchenne muscular dystrophyR01NS120060 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI VILLALTA, SERGIO ARMANDO · 2020 to 2024
$2.5M
Disentangling the Epidermal Immune Crosstalk in Inflammatory Skin DiseaseF31AR083279 · NIAMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI MOSHENSKY, ALEXANDER · 2023 to 2025
$136k
NCI NIH HHS P01 CA288662NCI NIH HHS P30 CA062203NIAMS NIH HHS F31 AR083279NIAMS NIH HHS P30 AR075047NINDS NIH HHS R01 NS120060
6 · The paper itself

Abstract

The immune system can eradicate cancer, but various immunosuppressive mechanisms active within a tumor curb this beneficial response. However, unraveling the effects of multimodal interactions between tumor and immune cells and their contributions to tumor control using an experimental approach alone is time- and resource-intensive. To identify the critical immunological features associated with tumor control and escape, we built a mechanistic mathematical model of the interactions between CD8

Indexed as

CD8+ T cellscheckpoint blockade immunotherapydendritic cells (DCs)mathematical modelingTregs

Identifiers

PMID41279834
PMCPMC12637685

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.