Evidence map›Paper›PMID 41279832›Full record

ArticlebioRxiv : the preprint server for biology2025

Characterization of an Open-Channel Structure and Lateral Conduction Pathway in the Cation-Selective Pentameric Ligand-Gated Ion Channel, ELIC.

Mark J Arcario, Elizabeth J Wu-Chen, Jérôme Hénin, Grace Brannigan, Wayland W L Cheng

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Mark J ArcarioDepartment of Anesthesiology, School of Medicine, Washington University in Saint Louis, St. Louis, MO, 63110, USA.ORCID 0000-0001-5017-1519
Elizabeth J Wu-ChenDepartment of Anesthesiology, School of Medicine, Washington University in Saint Louis, St. Louis, MO, 63110, USA.
Jérôme HéninLaboratoire de Biochimie Théorique, Université Paris Cité, Paris, 75005, France.ORCID 0000-0003-2540-4098
Grace BranniganCenter for Computational and Integrative Biology, Rutgers University, Camden, NJ, 08103, USA.ORCID 0000-0001-8949-2694
Wayland W L ChengDepartment of Anesthesiology, School of Medicine, Washington University in Saint Louis, St. Louis, MO, 63110, USA.ORCID 0000-0002-9529-9820

Funding

Lipid Modulation of Ligand-Gated Ion ChannelsR35GM137957 · NIGMS · WASHINGTON UNIVERSITY · PI Wayland Wing-Lun Cheng · 2020 to 2026
$2.9M
Unraveling how Lipophilic Modulators Alter pLGIC Function via Interactions with the M4 Transmembrane HelixK08GM152844 · NIGMS · WASHINGTON UNIVERSITY · PI Mark Joseph Arcario · 2023 to 2026
$743k
NIGMS NIH HHS K08 GM152844NIGMS NIH HHS R35 GM137957
6 · The paper itself

Abstract

Open-channel structures of multiple pentameric ligand-gated ion channels (pLGIC) have been determined, including the prokaryotic model pLGIC, ELIC (

Identifiers

PMID41279832
PMCPMC12637682

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.