Evidence map›Paper›PMID 41279819›Full record

ArticlebioRxiv : the preprint server for biology2026

Divergent role of CD8 T cells with distinct metabolic phenotypes during curative radio-immunotherapy in hot versus cold tumors.

Alexa R Heaton, Nathaniel J Burkard, Anqi Gao, Anna Hoefges, Arika S Feils, Samantha K Burkard, Mildred A Felder, Noah W Tsarovsky, Daniel V Spiegelman, Garrett M Lublin and 7 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Alexa R HeatonMorgridge Institute for Research, Madison, WI, USA.ORCID 0000-0003-4144-5535
Nathaniel J BurkardDepartment of Biomedical Engineering, University of Wisconsin, Madison, WI, US.
Anqi GaoMcArdle Laboratory for Cancer Research, University of Wisconsin, Madison, WI, USA.ORCID 0000-0002-8383-4283
Anna HoefgesDepartment of Human Oncology, University of Wisconsin, Madison, WI, USA.ORCID 0000-0002-3712-4854
Arika S FeilsDepartment of Human Oncology, University of Wisconsin, Madison, WI, USA.ORCID 0000-0002-9349-4534
Samantha K BurkardDepartment of Computer Sciences, University of Wisconsin, Madison, WI, USA.ORCID 0009-0002-2783-2037
Mildred A FelderDepartment of Human Oncology, University of Wisconsin, Madison, WI, USA.
Noah W TsarovskyDepartment of Human Oncology, University of Wisconsin, Madison, WI, USA.ORCID 0000-0001-9036-3515
Daniel V SpiegelmanDepartment of Human Oncology, University of Wisconsin, Madison, WI, USA.ORCID 0000-0001-6450-3238
Garrett M LublinDepartment of Neuroscience, University of Wisconsin, Madison, WI, USA.
Alina A HamptonDepartment of Human Oncology, University of Wisconsin, Madison, WI, USA.ORCID 0009-0002-2997-3159
Aurora D'AmatoGlobal Health Institute, University of Wisconsin, Madison, WI, USA.ORCID 0009-0002-8940-0010
Huy Q DinhMcArdle Laboratory for Cancer Research, University of Wisconsin, Madison, WI, USA.ORCID 0000-0002-3307-1126
Alexander L RakhmilevichDepartment of Human Oncology, University of Wisconsin, Madison, WI, USA.ORCID 0000-0002-2686-9500
Amy K ErbeDepartment of Human Oncology, University of Wisconsin, Madison, WI, USA.ORCID 0000-0003-1175-4062
Paul M SondelDepartment of Pediatrics and Department of Human Oncology, University of Wisconsin, Madison, WI, USA.ORCID 0000-0002-0981-8875
Melissa C SkalaMorgridge Institute for Research, Madison, WI, USA.ORCID 0000-0002-6320-7637

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Justine Yang Bruce · 1985 to 2026
$142.6M
University of Wisconsin Institute for Clinical and Translational ResearchUL1TR002373 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI ELIZABETH S BURNSIDE, Allan R. Brasier · 2017 to 2026
$75.9M
Understanding and Overcoming Resistance to Immunotherapies in Childhood CancersU54CA232568 · NCI · CHILDREN'S HOSP OF PHILADELPHIA · PI MACKALL, CRYSTAL, MARIS, JOHN M · 2018 to 2022
$13.1M
Radionuclide Production and Radiochemistry Core Description CoreP01CA250972 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI KIM, KYUNGMANN · 2020 to 2024
$12.5M
Enhancing Antibody-directed Innate Immunity to Improve Cancer OutcomeR35CA197078 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI SONDEL, PAUL M · 2015 to 2021
$6.4M
Functional optical imaging for rapid, label-free predictions of treatment response and clonal evolution in patient-derived cancer organoidsR01CA272855 · NCI · MORGRIDGE INSTITUTE FOR RESEARCH, INC. · PI Dustin A Deming, Melissa Caroline Skala · 2023 to 2026
$3.1M
Label-free imaging of CAR T cell metabolismR01CA278051 · NCI · MORGRIDGE INSTITUTE FOR RESEARCH, INC. · PI Christian Capitini, Krishanu Saha · 2023 to 2026
$2.6M
Automated Tissue MicroarrayerS10OD023526 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI MATKOWSKYJ, KRISTINA A. · 2018 to 2018
$184k
NCATS NIH HHS UL1 TR002373NCI NIH HHS P01 CA250972NCI NIH HHS P30 CA014520NCI NIH HHS R01 CA272855NCI NIH HHS R01 CA278051NCI NIH HHS R35 CA197078NCI NIH HHS U54 CA232568NIH HHS S10 OD023526
6 · The paper itself

Abstract

Immunotherapy has potential for impactful cancer cures by empowering patients' own immune cells. We developed a radio-immunotherapy regimen that can cure large immunologically hot and cold murine tumors. Here, we explored the divergent role of CD8 T cells during this radio-immunotherapy in contrasting hot colon carcinoma versus cold melanoma. We introduced an immunocompetent mouse model with mCherry-expressing CD8 T cells to provide cell tracking

Identifiers

PMID41279819
PMCPMC12633444

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.