Evidence map›Paper›PMID 41279796›Full record

ArticlebioRxiv : the preprint server for biology2025

Temporal control of axonal floor plate crossing through a combination of incoherent feedforward and feedback loops of gene regulatory network regulating Robo3 expression.

Reut Sudakevitz-Merzbach, Madhuri Majumder, Gerard Elberg, Marah Bakhtan, Dina Rekler, Sophie Khazanov, Benjamin J Wheaton, Nissim Ben-Arie, Gilgi Friedlander, Chaya Kalcheim and 4 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Reut Sudakevitz-MerzbachDepartment of Medical Neurobiology, IMRIC, Hebrew University - Hadassah Medical School, Jerusalem, Israel.
Madhuri MajumderDepartment of Genetics, Silberman Institute of Life Sciences.
Gerard ElbergDepartment of Medical Neurobiology, IMRIC, Hebrew University - Hadassah Medical School, Jerusalem, Israel.
Marah BakhtanDepartment of Medical Neurobiology, IMRIC, Hebrew University - Hadassah Medical School, Jerusalem, Israel.
Dina ReklerDepartment of Medical Neurobiology, IMRIC, Hebrew University - Hadassah Medical School, Jerusalem, Israel.
Sophie KhazanovDepartment of Medical Neurobiology, IMRIC, Hebrew University - Hadassah Medical School, Jerusalem, Israel.
Benjamin J WheatonDepartment of Medical and Translational Biology, Umeå University, 901 97 Umeå, Sweden.
Nissim Ben-ArieDepartment of Cell and Developmental Biology, Institute of Life Sciences, Hebrew University of Jerusalem, Jerusalem, Israel.
Gilgi FriedlanderThe Mantoux Bioinformatics Institute of the Nancy and Stephen Grand Israel National Center for Personalized Medicine, Weizmann Institute of Science, Rehovot, Israel.
Chaya KalcheimEdmond and Lily Safra Center for Brain Sciences (ELSC), Hebrew University of Jerusalem-Hadassah Medical School, Jerusalem, Israel.
Sara Ivy WilsonDepartment of Medical and Translational Biology, Umeå University, 901 97 Umeå, Sweden.
Alexander JaworskiDepartment of Neuroscience, Brown University, Providence, RI, United States.ORCID 0000-0002-4596-5450
Miri AdlerDepartment of Genetics, Silberman Institute of Life Sciences.
Avihu KlarDepartment of Medical Neurobiology, IMRIC, Hebrew University - Hadassah Medical School, Jerusalem, Israel.ORCID 0000-0002-9248-2179

Funding

Regulation of Nervous System Wiring by the Robo3 Axon Guidance Receptor and its Ligand NELL2R01NS095908 · NINDS · BROWN UNIVERSITY · PI JAWORSKI, ALEXANDER · 2017 to 2021
$2.2M
NINDS NIH HHS R01 NS095908
6 · The paper itself

Abstract

Spinal commissural neurons play a fundamental role in motor control and sensory perception. Robo3, a receptor expressed on pre-crossing commissural axons, is required for midline crossing. Its downregulation in post-crossing axons is essential for forming synapses with contralateral CNS targets. We demonstrate that, at the transcriptional level, the dynamic expression of

Identifiers

PMID41279796
PMCPMC12636605

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.