Evidence map›Paper›PMID 41279769›Full record

ArticlebioRxiv : the preprint server for biology2025

RELB Reprograms Exhausted Tumor-Infiltrating Lymphocytes for Improved Adoptive Cell Therapy.

Christian D McRoberts Amador, Rachel E Conover, Michael C Brown, Liliana S Lyniv, Pamela K Noldner, Ying Zhou, Aretha R Gao, Sean R McCutcheon, Scott J Antonia, Charles A Gersbach

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Christian D McRoberts AmadorDepartment of Pharmacology and Cancer Biology, Duke University.
Rachel E ConoverCenter for Advanced Genomic Technologies, Duke University.
Michael C BrownDepartment of Neurosurgery, Duke University School of Medicine.
Liliana S LynivDuke Cancer Institute, Center for Cancer Immunotherapy, Duke University School of Medicine.
Pamela K NoldnerDuke Cancer Institute, Center for Cancer Immunotherapy, Duke University School of Medicine.
Ying ZhouDuke Cancer Institute, Center for Cancer Immunotherapy, Duke University School of Medicine.
Aretha R GaoDepartment of Biology, Duke University.
Sean R McCutcheonCenter for Advanced Genomic Technologies, Duke University.
Scott J AntoniaDuke Cancer Institute, Center for Cancer Immunotherapy, Duke University School of Medicine.
Charles A GersbachCenter for Advanced Genomic Technologies, Duke University.ORCID 0000-0003-1478-4013

Funding

The Duke FUNCTION Center: Pioneering the comprehensive identification of combinatorial noncoding causes of diseaseRM1HG011123 · NHGRI · DUKE UNIVERSITY · PI GREGORY E CRAWFORD, Raluca Gordan · 2020 to 2026
$21.9M
High-Throughput Functional Annotation of Gene Regulatory Elements and Variants Critical to Complex Cellular PhenotypesUM1HG012053 · NHGRI · DUKE UNIVERSITY · PI GREGORY E CRAWFORD, Charles A. Gersbach · 2021 to 2026
$10.7M
Cell and Molecular Biology Training ProgramT32GM142605 · NIGMS · DUKE UNIVERSITY · PI MICHAEL S BOYCE, Stefano Di Talia · 2021 to 2026
$3.7M
Epigenetic Programming of T Cells for Enhanced Cellular ImmunotherapyR01CA289574 · NCI · DUKE UNIVERSITY · PI Charles A. Gersbach · 2024 to 2026
$1.7M
NCI NIH HHS R01 CA289574NHGRI NIH HHS RM1 HG011123NHGRI NIH HHS UM1 HG012053NIGMS NIH HHS T32 GM142605
6 · The paper itself

Abstract

Tumor-infiltrating lymphocytes (TILs) are a promising autologous cell therapy to treat solid tumors. TILs are manufactured by expanding and reinfusing tumor-reactive T cells from tumor biopsies. Efficacy of TIL therapies has been limited by the heterogeneity of expanded TIL products and the high prevalence of dysfunctional exhausted CD8+ T cells (T

Identifiers

PMID41279769
PMCPMC12632383

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.