Evidence map›Paper›PMID 41279742›Full record

ArticlebioRxiv : the preprint server for biology2025

VTA dopamine neuron activity produces spatially organized value representations.

Alejandro Pan-Vazquez, Christopher A Zimmerman, Brenna McMannon, Julie M J Fabre, Miranta Louka, Tingying Jia, Yotam Sagiv, Steven J West, Mayo Faulkner, International Brain Laboratory and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Alejandro Pan-VazquezPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Christopher A ZimmermanPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.ORCID 0000-0002-6286-1485
Brenna McMannonPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Julie M J FabrePrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Miranta LoukaPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Tingying JiaPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Yotam SagivPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Steven J WestSainsbury Wellcome Centre, University College London, London, UK.
Mayo FaulknerInstitute of Neurology, University College London, London, UK.
International Brain Laboratory
Peter DayanMax Planck Institute for Biological Cybernetics, Tübingen, Germany.
Ilana B WittenPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.ORCID 0000-0003-0548-2160

Funding

State-dependent Decision-making in Brainwide Neural CircuitsU19NS123716 · NINDS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI WITTEN, ILANA · 2021 to 2025
$18.2M
Individual differences through self-reinforcement of suboptimal strategiesDP1MH136573 · NIMH · PRINCETON UNIVERSITY · PI Ilana Witten · 2023 to 2026
$5.7M
Cross-region neural mechanisms that support conditioned taste aversionK99DA059957 · NIDA · PRINCETON UNIVERSITY · PI ZIMMERMAN, CHRISTOPHER · 2024 to 2025
$312k
NIDA NIH HHS K99 DA059957NIMH NIH HHS DP1 MH136573NINDS NIH HHS U19 NS123716Wellcome Trust
6 · The paper itself

Abstract

How does the activity of midbrain dopamine (DA) neurons reinforce actions? A prominent hypothesis is that the activity of ventral tegmental area (VTA) DA neurons instructs representations of predicted reward, or value, in downstream neurons

Identifiers

PMID41279742
PMCPMC12637434

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.