Evidence map›Paper›PMID 41279738›Full record

ArticlebioRxiv : the preprint server for biology2025

A phenotype-structured PDE framework for investigating the role of hypoxic memory on tumor invasion under cyclic hypoxia.

Gopinath Sadhu, Paras Jain, Jason Thomas George, Mohit Kumar Jolly

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Gopinath SadhuDepartment of Bioengineering, Indian Institute of Science, Bengaluru, 560012, Karnataka, India.
Paras JainDepartment of Bioengineering, Indian Institute of Science, Bengaluru, 560012, Karnataka, India.
Jason Thomas GeorgeDepartment of Biomedical Engineering, Texas A&M University College Station, TX, USA.
Mohit Kumar JollyDepartment of Bioengineering, Indian Institute of Science, Bengaluru, 560012, Karnataka, India.ORCID 0000-0002-6631-2109

Funding

Quantifying phenotypic adaptation of biological systems in dynamic environmentsR35GM155458 · NIGMS · TEXAS ENGINEERING EXPERIMENT STATION · PI Jason George · 2024 to 2026
$1.1M
NIGMS NIH HHS R35 GM155458
6 · The paper itself

Abstract

Tumor growth and angiogenesis drive complex spatiotemporal variation in micro-environmental oxygen levels. Previous experimental studies have observed that cancer cells exposed to chronic hypoxia retained a phenotype characterized by enhanced migration and reduced proliferation, even after being shifted to normoxic conditions, a phenomenon which we refer to as

Indexed as

cyclic hypoxiahypoxic memoryphenotype structure modelTumor invasion

Identifiers

PMID41279738
PMCPMC12636499

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.