Evidence map›Paper›PMID 41279736›Full record

ArticlebioRxiv : the preprint server for biology2025

A Structure-Guided Kinase-Transcription Factor Interactome Atlas Reveals Docking Landscapes of the Kinome.

Ah-Ram Kim, Kerui Huang, Jared L Johnson, Tomer M Yaron-Barir, Keven Wang, Lewis C Cantley, Yanhui Hu, Norbert Perrimon

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ah-Ram KimDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0001-9597-6759
Kerui HuangDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0003-1866-8407
Jared L JohnsonDepartment of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
Tomer M Yaron-BarirDana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0001-6574-7314
Keven WangDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.
Lewis C CantleyDepartment of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-1298-7653
Yanhui HuDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0003-1494-1402
Norbert PerrimonDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0001-7542-472X

Funding

The RAS and P13K Pathways in Pancreatic AdenocarcinomaP01CA117969 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI KALLURI, RAGHU · 2006 to 2025
$41.7M
Tuberous Sclerosis-Pathway and PathogenesisP01CA120964 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI David J. Kwiatkowski · 2007 to 2026
$35.9M
Role of Phosphoinositides and Protein Kinases in the control of Cancer MetabolismR35CA197588 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI LEWIS C. CANTLEY · 2016 to 2026
$10.2M
Characterization of the Insulin to Autophagy Pathway in MusclesR01AR057352 · NIAMS · HARVARD MEDICAL SCHOOL · PI NORBERT PERRIMON · 2010 to 2026
$8.2M
Functional genomics resources for the Drosophila - TR&D3P41GM132087 · NIGMS · HARVARD MEDICAL SCHOOL · PI MOHR, STEPHANIE E · 2019 to 2023
$6.8M
NCI NIH HHS P01 CA117969NCI NIH HHS P01 CA120964NCI NIH HHS R35 CA197588NIAMS NIH HHS R01 AR057352NIGMS NIH HHS P41 GM132087
6 · The paper itself

Abstract

Protein kinases orchestrate cellular processes through phosphorylation, yet the structural basis for their specific binding partner interactions remains largely unmapped. Here, we present a structure-guided atlas of the human and

Identifiers

PMID41279736
PMCPMC12632555

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.