Evidence map›Paper›PMID 41279711›Full record

ArticlebioRxiv : the preprint server for biology2025

Tau4RD fibril polymorphism is imprinted during early aggregation.

Ellie I James, Mason Saunders, Kelly K Lee, Miklos Guttman, Abhinav Nath

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ellie I JamesDepartment of Medicinal Chemistry, University of Washington, Seattle, WA.ORCID 0000-0001-6737-948X
Mason SaundersDepartment of Medicinal Chemistry, University of Washington, Seattle, WA.
Kelly K LeeDepartment of Medicinal Chemistry, University of Washington, Seattle, WA.ORCID 0000-0001-5577-9873
Miklos GuttmanDepartment of Medicinal Chemistry, University of Washington, Seattle, WA.ORCID 0000-0003-2419-1334
Abhinav NathDepartment of Medicinal Chemistry, University of Washington, Seattle, WA.ORCID 0000-0002-2895-2973

Funding

Pharmacological Sciences SupplementT32GM007750 · NIGMS · UNIVERSITY OF WASHINGTON · PI ATKINS, WILLIAM M · 1985 to 2023
$12.6M
Hybrid structural mass spectrometry for rapid site-specific glycan structural elucidationR01GM127579 · NIGMS · UNIVERSITY OF WASHINGTON · PI GUTTMAN, MIKLOS · 2018 to 2021
$1.7M
ThermoFisher Scientific Orbitrap Eclipse with ETD and UVPDS10OD030237 · OD · UNIVERSITY OF WASHINGTON · PI GUTTMAN, MIKLOS · 2022 to 2022
$1.2M
NIGMS NIH HHS R01 GM127579NIGMS NIH HHS T32 GM007750NIH HHS S10 OD030237
6 · The paper itself

Abstract

Microtubule-associated protein tau forms characteristic fibrillar species in many neurodegenerative diseases. Neurofibrillary tangles, tau deposits observed in Alzheimer's disease (AD), contain a mixture of amyloid-type polymorphic fibrils called paired helical filaments (PHFs) and straight filaments. The formation of heterogenous fibril populations is observed in other diseases and when tau aggregation is induced

Identifiers

PMID41279711
PMCPMC12632897

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.