Evidence map›Paper›PMID 41279691›Full record

ArticlebioRxiv : the preprint server for biology2025

Early menopause is associated with reduced global brain activity.

Xufu Liu, Liying Luo, Laura Pritschet, Yutong Mao, Feng Han, David N Proctor, Xiao Liu

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xufu LiuDepartment of Biomedical Engineering, The Pennsylvania State University, University Park, PA, 16802, USA.
Liying LuoDepartment of Sociology and Criminology, The Pennsylvania State University, University Park, Pennsylvania, 16801, USA.
Laura PritschetDepartment of Psychiatry, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Yutong MaoDepartment of Biomedical Engineering, The Pennsylvania State University, University Park, PA, 16802, USA.
Feng HanDepartment of Biomedical Engineering, The Pennsylvania State University, University Park, PA, 16802, USA.
David N ProctorDepartment of Kinesiology, The Pennsylvania State University, University Park, PA, 16801, USA.
Xiao LiuDepartment of Biomedical Engineering, The Pennsylvania State University, University Park, PA, 16802, USA.

Funding

The role of brain arousal in resting-state functional MRIR01NS113889 · NINDS · PENNSYLVANIA STATE UNIVERSITY, THE · PI LIU, XIAO · 2020 to 2024
$1.8M
Multimodal study of infra-slow propagating brain activityRF1MH123247 · NIMH · PENNSYLVANIA STATE UNIVERSITY, THE · PI LIU, XIAO · 2020 to 2020
$1.2M
Elucidating the role of endocrine aging as a risk factor for Alzheimer's DiseaseK00AG079790 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Laura Pritschet · 2024 to 2026
$228k
NIA NIH HHS K00 AG079790NIMH NIH HHS RF1 MH123247NINDS NIH HHS R01 NS113889
6 · The paper itself

Abstract

Menopause affects the aging process in women through significant ovarian hormone production decline in midlife. Women who experience early menopause face an accelerated physiological aging rate, along with impaired memory and increased risks of neurodegenerative diseases. However, it remains elusive how the timing of menopause affects brain activity, which could be crucial for understanding menopause-related acceleration of aging and increased risk of dementia. Recent studies have revealed a highly structured infra-slow (< 0.1 Hz) global brain activity across species and linked it to arousal and memory functions, as well as waste clearance in Alzheimer's diseases (AD). In this study, we examined how this global brain activity relates to age of menopause using resting-state fMRI data from the Human Connectome Project-Aging dataset. We found that women who experienced earlier menopause (mean menopausal age 45±3.5 yr) exhibited weaker global brain activity (

Indexed as

Early menopauseGlobal brain activityInfra-slow brain activityResting-state fMRI

Identifiers

PMID41279691
PMCPMC12632297

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.