Evidence map›Paper›PMID 41279678›Full record

ArticlebioRxiv : the preprint server for biology2025

The proton motive force maintains mtDNA euploidy by balancing mtDNA replication with cell proliferation.

Sneha P Rath, Vamsi K Mootha

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Sneha P RathDepartment of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA.ORCID 0000-0001-8839-1285
Vamsi K MoothaDepartment of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA.ORCID 0000-0001-9924-642X

Funding

Pilot & Feasibility ProgramP30DK043351 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Curtis Huttenhower · 1991 to 2026
$35.3M
Transgenic CoreP30DK057521 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI KAHN, BARBARA B. · 2000 to 2019
$31.4M
Molecular Determinants of Mitochondrial Genome Abundance and IntegrityK00CA212468 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI RATH, SNEHA PRAKASH · 2019 to 2022
$385k
A Systems Approach to Discover Sensors and Regulators of the Mitochondrial GenomeK99GM145848 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI RATH, SNEHA PRAKASH · 2023 to 2024
$250k
NCI NIH HHS K00 CA212468NIDDK NIH HHS P30 DK043351NIDDK NIH HHS P30 DK057521NIGMS NIH HHS K99 GM145848
6 · The paper itself

Abstract

Human mitochondrial DNA (mtDNA) encodes 13 essential components of the electron transport chain (ETC)

Identifiers

PMID41279678
PMCPMC12636550

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.