Evidence map›Paper›PMID 41279676›Full record

ArticlebioRxiv : the preprint server for biology2025

Control of Synaptic Communication through Molecularly Engineered Bioluminescence Light Emission and Sensing.

Ashley N Slaviero, Mansi Prakash, Elaheh Bell, Rachel Schumaker, Emmanuel L Crespo, Maya O Tree, Gerard G Lambert, Christopher I Moore, Nathan C Shaner, Diane Lipscombe and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Ashley N SlavieroBiochemistry, Cellular and Molecular Biology Graduate Program, Central Michigan University, Mt Pleasant, MI, USA.ORCID 0009-0004-8912-5041
Mansi PrakashCollege of Medicine, Central Michigan University, Mt Pleasant, MI, USA.
Elaheh BellBiochemistry, Cellular and Molecular Biology Graduate Program, Central Michigan University, Mt Pleasant, MI, USA.
Rachel SchumakerBiochemistry, Cellular and Molecular Biology Graduate Program, Central Michigan University, Mt Pleasant, MI, USA.
Emmanuel L CrespoBiochemistry, Cellular and Molecular Biology Graduate Program, Central Michigan University, Mt Pleasant, MI, USA.
Maya O TreeCollege of Medicine, Central Michigan University, Mt Pleasant, MI, USA.
Gerard G LambertDepartment of Neuroscience, University of California San Diego, La Jolla, CA, USA.
Christopher I MooreCarney Institute for Brain Science, Brown University, Providence, RI, USA.
Nathan C ShanerDepartment of Neuroscience, University of California San Diego, La Jolla, CA, USA.
Diane LipscombeCarney Institute for Brain Science, Brown University, Providence, RI, USA.
Ute HochgeschwenderBiochemistry, Cellular and Molecular Biology Graduate Program, Central Michigan University, Mt Pleasant, MI, USA.ORCID 0000-0002-7146-9119

Funding

Selective Control of Synaptically-Connected Circuit Elements by Interluminescence - Diversity Supplement SILVAGNOLIR01NS120832 · NINDS · CENTRAL MICHIGAN UNIVERSITY · PI HOCHGESCHWENDER, UTE H, MOORE, CHRISTOPHER I · 2021 to 2023
$3.4M
BioLuminescent OptoGenetics (BL-OG): A Novel and Versatile Strategy for NeuromodulationU01NS099709 · NINDS · CENTRAL MICHIGAN UNIVERSITY · PI HOCHGESCHWENDER, UTE H, MOORE, CHRISTOPHER I · 2016 to 2018
$2.4M
Genetically Encoded Light-Production and Light-Sensing for Neuronal ManipulationR21MH101525 · NIMH · DUKE UNIVERSITY · PI HOCHGESCHWENDER, UTE H · 2013 to 2015
$434k
NIMH NIH HHS R21 MH101525NINDS NIH HHS R01 NS120832NINDS NIH HHS U01 NS099709
6 · The paper itself

Abstract

Synapses are sites of intercellular communication between neurons and from neurons to target organs, and of signal integration that underly physiological and behavioral responses. We have developed a modular platform, Interluminescence (Int), for experimental control of synaptic transmission: bioluminescent light, generated by a luciferase oxidizing a luciferin, from a presynaptic neuron is used to activate transsynaptic optogenetic ion channels in the postsynaptic neuron. Two strategies can activate or silence postsynaptic neurons

Identifiers

PMID41279676
PMCPMC12636396

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.