Evidence map›Paper›PMID 41279670›Full record

ArticlebioRxiv : the preprint server for biology2026

Cell size modulates ferroptosis susceptibility.

Evgeny Zatulovskiy, Magdalena B Murray, Shuyuan Zhang, Scott J Dixon, Jan M Skotheim

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Evgeny ZatulovskiyDepartment of Biochemistry, University of Cambridge, Cambridge, CB2 1GA, UK.ORCID 0000-0002-7847-5829
Magdalena B MurrayDepartment of Biology, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0002-6306-4568
Shuyuan ZhangDepartment of Biology, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0002-6220-5998
Scott J DixonDepartment of Biology, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0001-6230-8199
Jan M SkotheimDepartment of Biology, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0001-8420-6820

Funding

Project 3: Defining and targeting mechanisms of E2F transcription factor regulationP01CA254867 · NCI · STANFORD UNIVERSITY · PI Seth Michael Rubin, Jan M Skotheim · 2022 to 2026
$8.9M
Characterizing the Regulation of FerroptosisR01GM122923 · NIGMS · STANFORD UNIVERSITY · PI Scott Dixon · 2017 to 2026
$3.4M
NCI NIH HHS P01 CA254867NIGMS NIH HHS R01 GM122923
6 · The paper itself

Abstract

Size is a fundamental property of cells that influences many aspects of their physiology. This is because cell size sets the scale for all subcellular components and drives changes in the composition of the proteome. Given that large and small cells differ in their biochemical composition, we hypothesize that they should also differ in how they respond to signals and make decisions. Here, we investigated how cell size affects susceptibility to cell death. We found that large cells are more resistant to ferroptosis caused by system x

Identifiers

PMID41279670
PMCPMC12633219

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.