ArticlebioRxiv : the preprint server for biology2025
Extracellular space diffusion modelling identifies distinct functional advantages of archetypical glutamatergic and GABAergic synapse geometries.
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The brain extracellular space (ECS) is a convoluted compartment of nano- and microscale interconnected ducts. A key step in signaling between neural cells is diffusion of signaling molecules through the ECS, yet, signaling is generally considered solely from the stance of cells and their properties. Where ECS diffusion is addressed, this is commonly done using volume-averaging techniques blind to individual signaling events and ECS geometry. We hypothesized that ECS geometry can shape local diffusion and thereby tune signaling arising from point-sources. To access the scale of individual transmitter release events and synapse geometries, we developed a computational diffusion model,
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