Evidence map›Paper›PMID 41279663›Full record

ArticlebioRxiv : the preprint server for biology2025

Human gut Bifidobacteria strains regulate host longevity via shared and divergent mechanisms in

Yuxin Li, Gabriela Diaz-Tang, Shuo Han

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Yuxin LiBiochemistry Graduate Program, Duke University School of Medicine, Durham, NC, USA.
Gabriela Diaz-TangMolecular Genetics and Microbiology Graduate Program, Duke University School of Medicine, Durham, NC, USA.ORCID 0000-0003-3002-3046
Shuo HanDepartment of Biochemistry, Duke University School of Medicine, Durham, NC, USA.ORCID 0000-0003-1181-351X

Funding

PILOT AND FEASIBILITY STUDIESP30DK034987 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ROBERT S. SANDLER · 1985 to 2026
$30.5M
NIDDK NIH HHS P30 DK034987
6 · The paper itself

Abstract

The human gut microbiome influences many aspects of host aging physiology. However, it is not clear how distinct bacterial strains interact with host aging pathways and different healthspan metrics. To investigate this question, we chose Bifidobacteria as our bacterial model. The Bifidobacteria genus contains diverse species that are enriched in both human infants and centenarians, suggesting that they may confer "youthful" effects in aging adults. We selected eleven strains from nine Bifidobacteria species that are commonly detected in human fecal samples. Using our human anaerobic gut bacteria-

Identifiers

PMID41279663
PMCPMC12632926

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.