ArticlebioRxiv : the preprint server for biology2025
Type 2 Diabetes and Obesity Alter Exercise Training-Induced Transcriptional Adaptations to Subcutaneous White Adipose Tissue.
Roeland J W Middelbeek, Jiekun Yang, Pasquale Nigro, Benjamin James, Danaé Papadopoulos, Laura K Simpson, Jeu Park, Maria Vamvini, Li-Lun Ho, Hui Zhang and 4 more
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
14 authors.
Roeland J W MiddelbeekSection on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-3862-8082 Jiekun YangComputer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0003-0920-052X Pasquale NigroSection on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-2918-8356 Benjamin JamesComputer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA.
Danaé PapadopoulosComputer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA.
Laura K SimpsonSection on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA.
Jeu ParkSection on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-5084-8067 Maria VamviniSection on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA.
Li-Lun HoComputer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA.
Hui ZhangSection on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA.
Nicholas P CarboneSection on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-2999-3192 Michael F HirshmanSection on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-8728-6379 Manolis KellisComputer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0001-7113-9630 Laurie J GoodyearSection on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-6299-2928 Funding
SPECIAL ASSAY COREP30DK036836 · NIDDK · JOSLIN DIABETES CENTER · PI JEAN E. SCHAFFER · 1986 to 2026
$50.5MTransgenic CoreP30DK057521 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI KAHN, BARBARA B. · 2000 to 2019
$31.4MTRAINING IN DIABETES AND METABOLISMT32DK007260 · NIDDK · JOSLIN DIABETES CENTER · PI LAURIE J GOODYEAR · 1986 to 2026
$13.6MNovel Mechanisms of Exercise Training Effects on Glucose HomeostasisR01DK099511 · NIDDK · JOSLIN DIABETES CENTER · PI LAURIE J GOODYEAR · 2014 to 2026
$6.5MTraining Program in Nutrition and MetabolismT32HD052961 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI GRINSPOON, STEVEN K. · 2005 to 2016
$1.3MHarvard Training Program in Bioinformatics Applied to Diabetes, Obesity and Metabolism.T32DK110919 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI FLOREZ, JOSE CARLOS, PATEL, CHIRAG J. · 2017 to 2021
$1.3MExercise Regulation of Human Adipose TissueR01DK112283 · NIDDK · JOSLIN DIABETES CENTER · PI GOODYEAR, LAURIE J · 2016 to 2018
$1.2MMechanisms of exercise effects in obese humans: sex-specific regulation of novel adipose tissue functionK23DK114550 · NIDDK · JOSLIN DIABETES CENTER · PI MIDDELBEEK, ROELAND J · 2018 to 2022
$956kMulti-omics approach to understanding the beneficial effects of exercise in diabetesF32DK126432 · NIDDK · JOSLIN DIABETES CENTER · PI VAMVINI, MARIA · 2020 to 2021
$227kNICHD NIH HHS T32 HD052961NIDDK NIH HHS F32 DK126432NIDDK NIH HHS K23 DK114550NIDDK NIH HHS P30 DK036836NIDDK NIH HHS P30 DK057521NIDDK NIH HHS R01 DK099511NIDDK NIH HHS R01 DK112283NIDDK NIH HHS T32 DK007260NIDDK NIH HHS T32 DK110919
6 · The paper itselfAbstract
White adipose tissue (WAT) dysfunction contributes to obesity-associated metabolic disease and type 2 diabetes (T2D). Rodent studies have demonstrated that exercise training improves WAT function, but molecular studies investigating exercise training effects on WAT in humans have been limited, particularly in the context of metabolic disease. Here, we defined the subcutaneous WAT (scWAT) transcriptome in middle-aged adults (10 male, 19 female) that were classified by lower BMI (<27 kg/m
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PMID41279622
PMCPMC12632298
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