Evidence map›Paper›PMID 41279580›Full record

ArticlebioRxiv : the preprint server for biology2025

Clonal dynamics of monozygotic twinning in early human embryogenesis.

Christopher Jongsoo Yoon, Chang Hyun Nam, Seung Mi Lee, Eun Saem Choi, Ji Hye Bae, Haemin Kim, Young Mi Jung, Joonoh Lim, Ryul Kim, Catherine Derom and 9 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Christopher Jongsoo YoonGraduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.ORCID 0000-0001-5714-7087
Chang Hyun NamGraduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.
Seung Mi LeeDepartment of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Republic of Korea.
Eun Saem ChoiDepartment of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Republic of Korea.
Ji Hye BaeDepartment of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Republic of Korea.
Haemin KimDepartment of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Republic of Korea.
Young Mi JungDepartment of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Republic of Korea.
Joonoh LimGraduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.
Ryul KimGraduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.
Catherine DeromDepartment of Human Structure and Repair, Ghent University, Ghent, Belgium.
Eline MeiresonDepartment of Human Structure and Repair, Ghent University, Ghent, Belgium.
Steven WeyersDepartment of Human Structure and Repair, Ghent University, Ghent, Belgium.
Jung Woo ParkKorea Institute of Science and Technology Information (KISTI), Daejeon, Republic of Korea.
Junehawk LeeKorea Institute of Science and Technology Information (KISTI), Daejeon, Republic of Korea.
Joohon SungDepartment of Epidemiology, School of Public Health, Seoul National University, Seoul, Republic of Korea.ORCID 0000-0002-5514-4189
Obi L GriffithDepartment of Medicine, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-0843-4271
Malachi GriffithDepartment of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Jong Kwan JunDepartment of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Republic of Korea.
Young Seok JuGraduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.

Funding

Tracing the timing of monozygotic twinning using somatic mutations.F30HD106744 · NICHD · WASHINGTON UNIVERSITY · PI YOON, CHRISTOPHER JONGSOO · 2022 to 2023
$85k
NICHD NIH HHS F30 HD106744
6 · The paper itself

Abstract

Monozygotic twins are derived from the split of a single zygote early in embryogenesis. Although it was hypothesized that the timing of twining is overall associated with fetal membrane configuration of twins, i.e., chorionicity and amnionicity, our understanding of early embryonic clonal dynamics underlying human twinning is limited. Here we explored the segregations of early embryonic lineages in 7 dichorionic diamniotic (

Identifiers

PMID41279580
PMCPMC12632306

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.