Evidence map›Paper›PMID 41279578›Full record

ArticlebioRxiv : the preprint server for biology2025

Phosphorylation of a conserved intrinsically disordered region is necessary for activation of a bacterial Hanks-type Ser/Thr kinase signaling pathway.

Noam Grunfeld, Erel Levine, Elizabeth A Libby

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Noam GrunfeldDepartment of Bioengineering, Northeastern University, Boston MA USA.
Erel LevineDepartment of Bioengineering, Northeastern University, Boston MA USA.
Elizabeth A LibbyDepartment of Bioengineering, Northeastern University, Boston MA USA.ORCID 0000-0003-2374-1015

Funding

Physiological and Developmental Role of Bacterial Ser/Thr KinasesR35GM147429 · NIGMS · NORTHEASTERN UNIVERSITY · PI Elizabeth Libby · 2022 to 2026
$2.0M
NIGMS NIH HHS R35 GM147429
6 · The paper itself

Abstract

Intrinsically disordered regions (IDRs) are found throughout all domains of life, yet their contribution to bacterial signaling has remained unclear. Here we show that phosphorylation of a conserved juxtamembrane IDR is necessary for activation of the bacterial Hanks-type Ser/Thr kinase-phosphatase PrkC/PrpC signaling pathway in

Indexed as

antibiotic sensingBacillus subtilisbacterial signal transductionintrinsically disordered regionPASTA kinaseSer/Thr kinaseSer/Thr phosphatase

Identifiers

PMID41279578
PMCPMC12636448

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.