Evidence map›Paper›PMID 41279573›Full record

ArticlebioRxiv : the preprint server for biology2025

Optimized reference region and the effect on test-retest reliability and detection of Parkinson's disease with [

Nikkita Khattar, David Matuskey, Jean-Dominique Gallezot, Mika Naganawa, Sophie E Holmes, Faranak Ebrahimian Sadabad, Mahsa Mayeli, Irina Esterlis, Christopher H van Dyck, Adam P Mecca and 6 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Nikkita KhattarDepartment of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0003-3484-2452
David MatuskeyDepartment of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT, USA.
Jean-Dominique GallezotDepartment of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0003-0399-8374
Mika NaganawaDepartment of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0002-4408-2621
Sophie E HolmesDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Faranak Ebrahimian SadabadDepartment of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT, USA.
Mahsa MayeliDepartment of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT, USA.
Irina EsterlisDepartment of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT, USA.
Christopher H van DyckDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Adam P MeccaDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Deepak Cyril D'SouzaDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Nabeel B NabulsiDepartment of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0001-8129-0051
Sjoerd J FinnemaAbbVie Inc., North Chicago, IL, USA.
Yiyun HuangDepartment of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT, USA.
Richard E CarsonDepartment of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT, USA.
Takuya ToyonagaDepartment of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0002-0369-8294

Funding

PET Imaging of Synaptic Density in Alzheimers DiseaseR01AG052560 · NIA · YALE UNIVERSITY · PI CARSON, RICHARD E., VAN DYCK, CHRISTOPHER H · 2017 to 2020
$3.2M
SV2A PET Imaging in Healthy Subjects and Epilepsy PatientsR01NS094253 · NINDS · YALE UNIVERSITY · PI CARSON, RICHARD E. · 2016 to 2020
$2.8M
In vivo synaptic and dopamine transporter imaging in Parkinson's diseaseR01NS124819 · NINDS · YALE UNIVERSITY · PI DAVID A MATUSKEY · 2022 to 2026
$2.7M
NIA NIH HHS R01 AG052560NINDS NIH HHS R01 NS094253NINDS NIH HHS R01 NS124819
6 · The paper itself

Abstract

[

Indexed as

Brain ImagingNeurodegenerationParkinson’s diseasePositron emission tomographySynapses/Dendrites

Identifiers

PMID41279573
PMCPMC12632983

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.