Evidence map›Paper›PMID 41279540›Full record

ArticlebioRxiv : the preprint server for biology2025

CO-STIMULATORY BLOCKADE PREVENTS INTRAGRAFT ACCRUAL OF CLASS-SWITCHED, ACTIVATED B CELLS DESPITE FAILING TO PREVENT T-CELL MEDIATED REJECTION.

J Timothy Caldwell, Tiffany Shi, Ashley R Burg, Ashley Koby, Krishna M Roskin, Anna L Peters, Erica A K DePasquale, E Steve Woodle, David A Hildeman

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

J Timothy CaldwellDivision of Nephrology & Hypertension, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Tiffany ShiDivision of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Ashley R BurgDivision of Nephrology & Hypertension, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Ashley KobyDivision of Nephrology & Hypertension, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Krishna M RoskinDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Anna L PetersDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Erica A K DePasqualeDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.ORCID 0000-0002-2430-6982
E Steve WoodleDivision of Transplantation, Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
David A HildemanDivision of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.ORCID 0000-0002-0421-8483

Funding

Stem Cell/Organoid and Genome Editing CoreP30DK078392 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI LEE ARMISTEAD DENSON · 2007 to 2026
$24.4M
Cincinnati Center for Clinical and Translational Sciences and TrainingUL1TR000077 · NCATS · UNIVERSITY OF CINCINNATI · PI HEUBI, JAMES E., TSEVAT, JOEL · 2012 to 2014
$9.9M
PEARL: Pathway Exploration and Analysis in Renal LupusUH2AR067688 · NIAMS · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI DIAMOND, BETTY, WOFSY, DAVID · 2014 to 2020
$9.0M
KL2 Training ProgramKL2TR001426 · NCATS · UNIVERSITY OF CINCINNATI · PI ZELLER, MARGARET H · 2015 to 2024
$6.8M
RESEARCH TRAINING IN PEDIATRIC NEPHROLOGYT32DK007695 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI DEVARAJAN, PRASAD · 1992 to 2023
$2.2M
Decoding human T-cell allospecificityR21AI169863 · NIAID · UNIVERSITY OF NOTRE DAME · PI BAKER, BRIAN M, HILDEMAN, DAVID A · 2023 to 2024
$464k
Single cell analysis of transplant rejectionR21AI142264 · NIAID · CINCINNATI CHILDRENS HOSP MED CTR · PI HILDEMAN, DAVID A · 2019 to 2020
$452k
Single Cell Analysis of Allowance CB8+ T Cells in Kidney Transplant RejectionF30AI167482 · NIAID · UNIVERSITY OF CINCINNATI · PI Tiffany Shi · 2023 to 2026
$173k
NCATS NIH HHS KL2 TR001426NCATS NIH HHS UL1 TR000077NIAID NIH HHS F30 AI167482NIAID NIH HHS R21 AI142264NIAID NIH HHS R21 AI169863NIAMS NIH HHS UH2 AR067688NIDDK NIH HHS P30 DK078392NIDDK NIH HHS T32 DK007695
6 · The paper itself

Abstract

Previously, we defined the transcriptomes and clonality of intragraft CD8

Identifiers

PMID41279540
PMCPMC12633403

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.