Evidence map›Paper›PMID 41279521›Full record

ArticlebioRxiv : the preprint server for biology2025

Geometric Tuning of Cytokine Receptor Association Modulates Synthetic Agonist Signaling.

Marc Expòsit, Mohamad Abedi, Aditya Krishnakumar, Shruti Jain, Ta-Yi Yu, Timothy R Hercus, Divij Mathew, Sophie Gray-Gaillard, Zhijie Chen, William S Grubbe and 9 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Marc ExpòsitDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID 0000-0002-2980-303X
Mohamad AbediDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID 0000-0001-9717-6288
Aditya KrishnakumarDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID 0000-0003-3461-0133
Shruti JainDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Ta-Yi YuDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Timothy R HercusThe Centre for Cancer Biology, SA Pathology and the University of South Australia, Adelaide, SA, Australia.ORCID 0000-0001-5290-9206
Divij MathewInstitute for Immunology and Immune Health, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.ORCID 0000-0002-8323-7358
Sophie Gray-GaillardInstitute for Immunology and Immune Health, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.ORCID 0000-0002-4884-5956
Zhijie ChenDepartment of Chemistry, University of Chicago, Chicago, IL, USA.
William S GrubbeDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID 0000-0002-4933-2626
Andrew FavorDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID 0000-0002-9977-2785
Winnie L KanThe Centre for Cancer Biology, SA Pathology and the University of South Australia, Adelaide, SA, Australia.ORCID 0000-0002-5844-7644
Thomas SchlichthaerleDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID 0000-0003-4444-2575
Wei ChenDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID 0000-0002-5255-4166
Michael W ParkerAustralian Cancer Research Foundation (ACRF) Rational Drug Discovery Centre, St. Vincent's Institute of Medical Research, Fitzroy, VIC, Australia.ORCID 0000-0002-3101-1138
Juan L MendozaPritzker School of Molecular Engineering, University of Chicago, Chicago, IL, USA.ORCID 0000-0001-6972-7476
Angel F LopezThe Centre for Cancer Biology, SA Pathology and the University of South Australia, Adelaide, SA, Australia.ORCID 0000-0001-7430-0135
E John WherryInstitute for Immunology and Immune Health, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.ORCID 0000-0003-0477-1956
David BakerDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID 0000-0001-7896-6217

Funding

TARGETING ROR1 WITH CHIMERIC ANTIGEN RECEPTOR MODIFIED T CELLSR01CA114536 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Sylvain Simon · 2005 to 2026
$8.4M
Design of de novo interleukin mimics for targeted immunotherapyR01CA240339 · NCI · UNIVERSITY OF WASHINGTON · PI BAKER, DAVID · 2019 to 2023
$2.1M
NCI NIH HHS R01 CA114536NCI NIH HHS R01 CA240339
6 · The paper itself

Abstract

Cytokines signal by bringing receptor subunits together, but the role of receptor geometry in shaping signaling remains unclear because natural ligands enforce fixed assemblies. Here, we present a

Indexed as

Cell SignalingCytokine EngineeringProtein DesignSynthetic Biology

Identifiers

PMID41279521
PMCPMC12632830

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.