Evidence map›Paper›PMID 41279513›Full record

ArticlebioRxiv : the preprint server for biology2025

Differential Impact of Lymphocytes on Radiation Response in Autochthonous versus Transplant Sarcomas in Syngeneic Mice.

Yvonne M Mowery, Aastha Sobti, Alex M Bassil, Amy J Wisdom, Collin L Kent, Chang Su, Jonathan Himes, Eric S Xu, Nerissa T Williams, Lixia Luo and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Yvonne M MoweryDepartment of Radiation Oncology, University of Pittsburgh/UPMC Hillman Cancer Center.
Aastha SobtiDepartment of Radiation Oncology, University of Pittsburgh/UPMC Hillman Cancer Center.
Alex M BassilDepartment of Radiation Oncology, Duke University, Durham, NC, USA.
Amy J WisdomDepartment of Radiation Oncology, Duke University, Durham, NC, USA.ORCID 0000-0002-6098-5353
Collin L KentDepartment of Radiation Oncology, Duke University, Durham, NC, USA.
Chang SuDepartment of Radiation Oncology, Duke University, Durham, NC, USA.ORCID 0000-0003-4962-3797
Jonathan HimesDepartment of Radiation Oncology, Duke University, Durham, NC, USA.ORCID 0000-0001-8637-0069
Eric S XuDepartment of Radiation Oncology, Duke University, Durham, NC, USA.
Nerissa T WilliamsDepartment of Radiation Oncology, Duke University, Durham, NC, USA.
Lixia LuoDepartment of Radiation Oncology, Duke University, Durham, NC, USA.
David G KirschDepartment of Radiation Oncology, Duke University, Durham, NC, USA.

Funding

Advancing Cancer Therapy through Ground Breaking Research in Radiation BiologyR35CA197616 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI David Guy Kirsch · 2016 to 2026
$10.7M
Employing Novel Primary Mouse Models of Head and Neck Cancer to Overcome Chemoradiation ResistanceK08DE029887 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MOWERY, YVONNE MARIE · 2020 to 2024
$804k
Image-Guided Radiation Therapy System for Small AnimalsS10OD028575 · OD · DUKE UNIVERSITY · PI PALMER, GREGORY MATHEW · 2021 to 2021
$600k
NCI NIH HHS R35 CA197616NIDCR NIH HHS K08 DE029887NIH HHS S10 OD028575
6 · The paper itself

Abstract

Preclinical studies in transplant tumor models showing high cure rates with combined radiotherapy (RT) and immunotherapy have rarely translated to clinical success, and studies in autochthonous tumor models are limited. We hypothesized that lymphocytes differentially affect RT response in transplant versus autochthonous tumor models. Here, we compared tumor onset and growth delay after 0 or 20 Gy for autochthonous versus transplant soft tissue sarcomas in

Indexed as

immune surveillanceimmunotherapylymphocytesmouse modelsradiation therapy

Identifiers

PMID41279513
PMCPMC12632375

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.