Evidence map›Paper›PMID 41279502›Full record

ArticlebioRxiv : the preprint server for biology2025

Ezequiel Calvo-Roitberg, Jesse W Lehman, Edric Tam, Shaimae Elhajjajy, Barbara E Engelhardt, Athma A Pai

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ezequiel Calvo-RoitbergRNA Therapeutics Institute, UMass Chan Medical School, Worcester, MA.ORCID 0000-0002-2431-515X
Jesse W LehmanRNA Therapeutics Institute, UMass Chan Medical School, Worcester, MA.
Edric TamDepartment of Biomedical Data Science, Stanford University, Stanford, CA.ORCID 0000-0003-4469-1168
Shaimae ElhajjajyDepartment of Genomics and Computational Biology, UMass Chan Medical School, Worcester, MA.
Barbara E EngelhardtDepartment of Biomedical Data Science, Stanford University, Stanford, CA.ORCID 0000-0002-6139-7334
Athma A PaiRNA Therapeutics Institute, UMass Chan Medical School, Worcester, MA.ORCID 0000-0002-7995-9948

Funding

Tracking transcriptome diversity in real-timeR35GM133762 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Athma A Pai · 2019 to 2026
$3.3M
A kinetic framework to map the genetic determinants of alternative RNA isoform expressionR01HG012967 · NHGRI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Barbara Engelhardt, Athma A Pai · 2023 to 2026
$3.0M
Innate Immunity Training ProgramT32AI095213 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SILVERMAN, NEAL · 2011 to 2025
$2.5M
Methods to build and annotate tissue atlases using spatial genomic dataR01HG013736 · NHGRI · J. DAVID GLADSTONE INSTITUTES · PI Barbara Engelhardt · 2024 to 2026
$2.5M
A unified probabilistic model and software implementation for analysis of nascent RNA sequencing dataR01HG012944 · NHGRI · COLD SPRING HARBOR LABORATORY · PI Adam Charles Siepel · 2024 to 2026
$1.7M
NHGRI NIH HHS R01 HG012944NHGRI NIH HHS R01 HG012967NHGRI NIH HHS R01 HG013736NIAID NIH HHS T32 AI095213NIGMS NIH HHS R35 GM133762
6 · The paper itself

Abstract

Nascent RNA sequencing offers profound insights into transcriptional dynamics, yet there are substantial challenges to analyzing these data. The development of proper computational tools necessitates realistic benchmarking datasets that reflect biological variability and technical biases. We present

Identifiers

PMID41279502
PMCPMC12637524

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.