Evidence map›Paper›PMID 41279460›Full record

ArticlebioRxiv : the preprint server for biology2025

Nitric oxide tunes secreted metabolite bioactivity.

Zachery R Lonergan, Sarah L Weisflog, Matthew Scurria, Jinyang Li, Korbinian Thalhammer, Osvaldo Gutierrez, Stuart J Conway, Dianne K Newman

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Zachery R LonerganDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125.ORCID 0000-0001-7694-2166
Sarah L WeisflogDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125.
Matthew ScurriaDepartment of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095.
Jinyang LiDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125.
Korbinian ThalhammerDivision of Geological and Planetary Sciences, California Institute of Technology, Pasadena, CA 91125.
Osvaldo GutierrezDepartment of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095.
Stuart J ConwayDepartment of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095.ORCID 0000-0002-5148-117X
Dianne K NewmanDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125.ORCID 0000-0003-1647-1918

Funding

New Directions in Sustainable Open-Shell Radical C-C Bond Formations Enabled by Merging Modern Computational and Experimental MethodsR35GM137797 · NIGMS · UNIV OF MARYLAND, COLLEGE PARK · PI Osvaldo Gutierrez · 2020 to 2026
$2.7M
Testing the hypothesis that microbial energetic hijacking of the CF immune response selects for specific pathogens during lung function decline- Diversity SupplementR01HL152190 · NHLBI · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI NEWMAN, DIANNE K · 2020 to 2023
$2.0M
Uncovering mechanisms of nitric oxide detoxification and reactivity in Pseudomonas aeruginosaK22AI182146 · NIAID · RUTGERS, THE STATE UNIV OF N.J. · PI Zachery Lonergan · 2025 to 2026
$263k
NHLBI NIH HHS R01 HL152190NIAID NIH HHS K22 AI182146NIGMS NIH HHS R35 GM137797
6 · The paper itself

Abstract

The radical nitric oxide (·NO) is short-lived but has imprinted itself on many aspects of physiology and disease. ·NO's rapid production and consumption, coupled with its intrinsic reactivity, drive its biological importance; thus, defining mechanisms and targets of ·NO reactivity is necessary to assess its fate and impact. Cellular small molecules are a major class of ·NO-reactive targets, possessing a variety of molecular functionalities that can react with ·NO. Yet the capacity for secreted small molecules to react with ·NO, as well as the biological consequences of such reactivity, have received little attention. Here, we explore the reactivity of ·NO with phenazine metabolites, microbially-derived secreted small molecules that possess antibiotic properties and can modulate their microenvironment. Using

Identifiers

PMID41279460
PMCPMC12637565

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.