Evidence map›Paper›PMID 41279446›Full record

ArticlebioRxiv : the preprint server for biology2025

Splicing of a core clock gene regulates seasonal adaptations by a winter gating mechanism.

S Hidalgo, R Del Rio, C A Tabuloc, L A Perez Hernandez, A L Berry, Y D Cai, K M Lewald, J C Chiu

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

S HidalgoDepartment of Entomology and Nematology, College of Agriculture, University of California, Davis. CA, USA.
R Del RioDepartment of Entomology and Nematology, College of Agriculture, University of California, Davis. CA, USA.
C A TabulocDepartment of Entomology and Nematology, College of Agriculture, University of California, Davis. CA, USA.
L A Perez HernandezDepartment of Entomology and Nematology, College of Agriculture, University of California, Davis. CA, USA.
A L BerryDepartment of Integrative Physiology and Neuroscience, College of Veterinary Medicine, Washington State University, Pullman. WA, USA.
Y D CaiDepartment of Entomology and Nematology, College of Agriculture, University of California, Davis. CA, USA.
K M LewaldDepartment of Entomology and Nematology, College of Agriculture, University of California, Davis. CA, USA.
J C ChiuDepartment of Entomology and Nematology, College of Agriculture, University of California, Davis. CA, USA.ORCID 0000-0001-7613-8127

Funding

Non-transcriptional regulation of circadian physiologyR01DK124068 · NIDDK · UNIVERSITY OF CALIFORNIA AT DAVIS · PI JOANNA Chungyen CHIU · 2019 to 2026
$3.1M
Activation of immune receptor signaling by a sulfated peptideR01GM122968 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI RONALD, PAMELA C · 2017 to 2020
$2.1M
Integration of seasonal cues to modulate neuronal plasticityR00NS133470 · NINDS · WASHINGTON STATE UNIVERSITY · PI Sergio Ignacio Hidalgo Sotelo · 2025 to 2026
$498k
Integration of seasonal cues to modulate neuronal plasticityK99NS133470 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HIDALGO SOTELO, SERGIO IGNACIO · 2023 to 2024
$211k
NIDDK NIH HHS R01 DK124068NIGMS NIH HHS R01 GM122968NINDS NIH HHS K99 NS133470NINDS NIH HHS R00 NS133470
6 · The paper itself

Abstract

Seasons bring changes to the environment. Many organisms adjust their physiology and behavior in response to seasonal changes in order to survive. Although the molecular mechanisms mediating the integration of seasonal cues are still unclear, the working model indicates the involvement of the circadian clock. Notably, the circadian neuropeptide Pigment Dispersing Factor (PDF), an output of the circadian clock, has been shown to alter its expression and activity in response to seasonal changes to facilitate seasonal adaptations in insects. Here, we show that the alternative splicing (AS) of a circadian clock gene,

Indexed as

DrosophilaPDFphotoperiodseasonal physiologysplicingtimeless

Identifiers

PMID41279446
PMCPMC12637415

What OpenQuestion holds

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LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.