Evidence map›Paper›PMID 41279445›Full record

ArticlebioRxiv : the preprint server for biology2025

Derivation of functional early gestation decidual natural killer cell subtypes from induced pluripotent stem cells.

Virginia Chu Cheung, Carly DaCosta, Jennifer Jaimez, Harneet Arora, Christine Caron, Jaroslav Slamecka, Manuel Fierro, Morgan Meads, Kathleen Fisch, Robert E Morey and 5 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Virginia Chu CheungDepartment of Pathology, School of Medicine, University of California San Diego, La Jolla, CA,92093, USA.
Carly DaCostaDepartment of Pathology, School of Medicine, University of California San Diego, La Jolla, CA,92093, USA.
Jennifer JaimezDepartment of Pathology, School of Medicine, University of California San Diego, La Jolla, CA,92093, USA.
Harneet AroraDepartment of Pathology, School of Medicine, University of California San Diego, La Jolla, CA,92093, USA.
Christine CaronDepartment of Pathology, School of Medicine, University of California San Diego, La Jolla, CA,92093, USA.
Jaroslav SlameckaDepartment of Pathology, School of Medicine, University of California San Diego, La Jolla, CA,92093, USA.
Manuel FierroSanford Consortium for Regenerative Medicine.
Morgan MeadsDepartment of Pathology, School of Medicine, University of California San Diego, La Jolla, CA,92093, USA.
Kathleen FischCenter for Perinatal Discovery, University of California San Diego, La Jolla, CA, 92093, USA.
Robert E MoreyDepartment of Pathology, School of Medicine, University of California San Diego, La Jolla, CA,92093, USA.
Devika PantDepartment of Pathology, School of Medicine, University of California San Diego, La Jolla, CA,92093, USA.
Dan S KaufmanSanford Consortium for Regenerative Medicine.
Mariko HoriiDepartment of Pathology, School of Medicine, University of California San Diego, La Jolla, CA,92093, USA.
Jack D BuiDepartment of Pathology, School of Medicine, University of California San Diego, La Jolla, CA,92093, USA.
Mana M ParastDepartment of Pathology, School of Medicine, University of California San Diego, La Jolla, CA,92093, USA.

Funding

UC San Diego Clinical and Translational Research InstituteUL1TR001442 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S, HOGARTH, MICHAEL · 2015 to 2024
$88.3M
TRAINING IN REPRODUCTIVE SCIENCEST32HD007203 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PAMELA L MELLON · 1988 to 2026
$4.8M
Modeling human trophoblast-NK cell interactions in term and preterm birthR01HD102639 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BUI, JACK D, PARAST, MANA M · 2021 to 2025
$2.6M
Modeling Preeclampsia Using Human Pluripotent Stem CellsR00HD091452 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HORII, MARIKO · 2020 to 2022
$737k
Illumina NovaSeq 6000 Sequencing SystemS10OD026929 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JEPSEN, KRISTEN LYNN · 2019 to 2019
$600k
Probing and modeling decidual natural killer cells in preterm birthF32HD108944 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHEUNG, VIRGINIA CHU · 2022 to 2024
$147k
NCATS NIH HHS UL1 TR001442NICHD NIH HHS F32 HD108944NICHD NIH HHS R00 HD091452NICHD NIH HHS R01 HD102639NICHD NIH HHS T32 HD007203NIH HHS S10 OD026929
6 · The paper itself

Abstract

Abnormal decidual natural killer cell (dNK) function is linked to pregnancy complications occurring in both early and late stages of gestation, including recurrent pregnancy loss, preeclampsia, and preterm birth. Exploration of dNK heterogeneity as it relates to function is an active area of research; however, most of this work has focused on early gestation. We applied flow cytometric and transcriptomic single cell definitions of dNK subtypes to dNK at the chorioamniotic membranes (CAM) and basal plate (BP) of the placenta at term. We found decreased low-effector-function dNK1 and increased high-effector-function dNK3 abundance at term. In comparison to BP-dNK, CAM-dNK had greater abundance of moderate-effector-function dNK2 and lower expression of inhibitory CD9. We applied this knowledge to establish a protocol for differentiation of induced pluripotent stem cells (iPSC) into CD45

Identifiers

PMID41279445
PMCPMC12637421

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.