Evidence map›Paper›PMID 41279437›Full record

ArticlebioRxiv : the preprint server for biology2025

Hypoxia-inducible factors drive miRNA-mediated downregulation of

Soma Seal, Rebecca A Luchtel, Talia Akram, Bogdan Isaila, Kent T Perry, Daniele Procissi, Sassan Hafizi, Niraj K Shenoy

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Soma SealRobert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL.
Rebecca A LuchtelRobert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL.
Talia AkramRobert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL.
Bogdan IsailaRobert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL.
Kent T PerryRobert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL.
Daniele ProcissiDepartment of Radiology (Basic and Translational Radiology Research), Northwestern University Feinberg School of Medicine, Chicago, IL.
Sassan HafiziSchool of Medicine, Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, UK.
Niraj K ShenoyRobert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL.

Funding

Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Devalingam Mahalingam · 1993 to 2026
$153.9M
Two-Spirit Films in Indigenous Cancer HealthP30CA016056 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI CANDACE S JOHNSON · 1985 to 2026
$116.6M
NCI NIH HHS P30 CA016056NCI NIH HHS P30 CA060553
6 · The paper itself

Abstract

Clear cell renal cell carcinoma (ccRCC) is characterized by pseudohypoxic signaling as well as metabolic and epigenetic aberrations of increasing severity during its pathogenesis and progression. Upon identifying that the markedly lower expression of

Indexed as

clear cell renal cell carcinomaHypoxia inducible factorskidney cancerL-2-hydroxyglutarate dehydrogenase

Identifiers

PMID41279437
PMCPMC12637520

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.