Evidence map›Paper›PMID 41279417›Full record

ArticlebioRxiv : the preprint server for biology2025

A Yeast-Based High-Throughput Screening Platform for the Discovery of Novel pre-mRNA Splicing Modulators.

Sierra L Love, Henrik Vollmer, Ya-Chu Chang, Joshua C Paulson, Tucker J Carrocci, Melissa S Jurica, Hai Dang Nguyen, Aaron A Hoskins

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Sierra L LoveGenetics Training Program, University of Wisconsin-Madison, Madison, WI 53706.ORCID 0000-0003-3254-9009
Henrik VollmerDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706.
Ya-Chu ChangDepartment of Pharmacology, University of Minnesota, Minneapolis, MN 55455.
Joshua C PaulsonDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706.
Tucker J CarrocciDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706.
Melissa S JuricaCenter for Molecular Biology of RNA, University of California-Santa Cruz, Santa Cruz, CA 95064.ORCID 0000-0002-4488-1386
Hai Dang NguyenDepartment of Pharmacology, University of Minnesota, Minneapolis, MN 55455.ORCID 0000-0002-4200-8778
Aaron A HoskinsDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706.ORCID 0000-0002-9777-519X

Funding

PREDOCTORAL TRAINING PROGRAM IN GENETICST32GM007133 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI PERNA, NICOLE T · 1985 to 2023
$16.5M
TRAINING GRANT IN MICROBIOLOGY/CANCER RESEARCHT32CA009138 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Scott M. Dehm · 1985 to 2026
$11.3M
Interpreting the Structure of the SpliceosomeR01GM072649 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI JURICA, MELISSA S · 2006 to 2016
$2.7M
Implications of PARP1 in myelodysplastic syndromes and targeted therapyR01HL163011 · NHLBI · UNIVERSITY OF MINNESOTA · PI Dang Hai Nguyen · 2022 to 2026
$2.5M
NCI NIH HHS T32 CA009138NHLBI NIH HHS R01 HL163011NIGMS NIH HHS R01 GM072649NIGMS NIH HHS T32 GM007133
6 · The paper itself

Abstract

Pre-mRNA splicing is a crucial process in eukaryotic gene expression, and splicing dysregulation has been linked to various diseases. However, very few small molecules have been discovered that can modulate spliced mRNA formation or inhibit the splicing machinery itself. This study presents a novel high-throughput screening (HTS) platform for identifying compounds that modulate splicing. Our platform comprises a two-tiered screening approach: a primary screen measuring growth inhibition in sensitized in

Indexed as

high-throughput screeninhibitorsmodulatorspre-mRNA splicingSF3B1yeast

Identifiers

PMID41279417
PMCPMC12633283

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.