Evidence map›Paper›PMID 41279414›Full record

ArticlebioRxiv : the preprint server for biology2025

Genetic background and transient prenatal disruption of vitamin A signaling determine susceptibility to airway hyperresponsiveness in mice.

Takehiro Otoshi, Ayyappa K S Kameshwar, Benjamin D Kotton, Yoshinori Seki, Zachary Cardell, Ke Xiangyi, Yuta Matsuno, Pooja Rajaram, Youn-Kyung Kim, Sarah M Sharpton and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Takehiro OtoshiColumbia Center for Human Development, Department of Medicine, Division of Pulmonary Allergy and Critical Care Medicine, and Department of Genetics and Development, Columbia University, New York, NY, USA.
Ayyappa K S KameshwarDepartment of Nutrition, Texas A&M University, College Station, TX, USA.
Benjamin D KottonColumbia Center for Human Development, Department of Medicine, Division of Pulmonary Allergy and Critical Care Medicine, and Department of Genetics and Development, Columbia University, New York, NY, USA.
Yoshinori SekiDepartment of Nutrition, Texas A&M University, College Station, TX, USA.
Zachary CardellDepartment of Nutrition, Texas A&M University, College Station, TX, USA.
Ke XiangyiColumbia Center for Human Development, Department of Medicine, Division of Pulmonary Allergy and Critical Care Medicine, and Department of Genetics and Development, Columbia University, New York, NY, USA.
Yuta MatsunoDepartment of Nutrition, Texas A&M University, College Station, TX, USA.
Pooja RajaramDepartment of Nutrition, Texas A&M University, College Station, TX, USA.
Youn-Kyung KimDepartment of Food Science and Rutgers Center for Lipid Research, and New Jersey Institute for Food, Nutrition, and Health, Rutgers University, New Brunswick, NJ, USA.
Sarah M SharptonMolecular Genomics Core, Institute for Genome Sciences and Society, Texas A&M University, College Station, TX, USA.
Loredana QuadroDepartment of Food Science and Rutgers Center for Lipid Research, and New Jersey Institute for Food, Nutrition, and Health, Rutgers University, New Brunswick, NJ, USA.
Wellington V CardosoColumbia Center for Human Development, Department of Medicine, Division of Pulmonary Allergy and Critical Care Medicine, and Department of Genetics and Development, Columbia University, New York, NY, USA.
Masako SuzukiDepartment of Nutrition, Texas A&M University, College Station, TX, USA.

Funding

Regulation of Progenitor Cell Plasticity in Lung Development and Disease-RepairR35HL166661 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Wellington V. Cardoso · 2023 to 2026
$4.4M
Structural basis of receptor-mediated cellular vitamin A uptakeR01EY027405 · NEI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI George Khelashvili, Filippo Mancia · 2017 to 2026
$4.4M
Investigating the effect of dysregulated vitamin D metabolism on kidney development following preterm birthR01DK136989 · NIDDK · UNIVERSITY OF VIRGINIA · PI Jennifer R Charlton, Kimberly Jean Reidy · 2024 to 2026
$2.1M
Role of Lipoprotein Assembly in Maternal-Fetal Transport of Beta-CaroteneR01HD094778 · NICHD · RUTGERS, THE STATE UNIV OF N.J. · PI HUSSAIN, M MAHMOOD, QUADRO, LOREDANA · 2019 to 2023
$1.9M
IMPACT OF PRENATAL VITAMIN A DEFICIENCY ON CELL FATE ALTERATIONS IN ADULT AIRWAY HYPERRESPONSIVENESSR01HL145302 · NHLBI · TEXAS A&M AGRILIFE RESEARCH · PI SUZUKI, MASAKO · 2020 to 2023
$1.6M
NEI NIH HHS R01 EY027405NHLBI NIH HHS R01 HL145302NHLBI NIH HHS R35 HL166661NICHD NIH HHS R01 HD094778NIDDK NIH HHS R01 DK136989
6 · The paper itself

Abstract

Airway structural changes and hyperresponsiveness (AHR), hallmarks of asthma, are crucially influenced by genetic variations and adverse exposures. While intrauterine environmental perturbations leading to dysfunctional lung development have been linked to adult pulmonary disease, still little is known about the developmental events leading to these postnatal abnormalities. Here, we provide evidence of genetic background playing a key role in this process. Using A/J and C57BL/6J mice known for their distinct susceptibility to AHR, we show that A/J but not C57BL/6J develop an aberrant airway smooth muscle (SM) program and AHR in adulthood when exposed transiently to a vitamin A/retinoic acid (RA)-disrupted intrauterine environment

Indexed as

airway hyperresponsivenessgenetic backgroundLung developmentmaternal-fetal interactionsretinoic acidsmooth muscle differentiationvitamin A

Identifiers

PMID41279414
PMCPMC12637646

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.