Evidence map›Paper›PMID 41279408›Full record

ArticlebioRxiv : the preprint server for biology2025

Coordinated and compartmentalized functions of CAII and CAIV establish a dual pH-regulatory mechanism essential for sperm maturation and capacitation.

Caroline Wiesehöfer, Cameron C Gardner, Aura Stoskus, M Agustina Battistone, Gunther Wennemuth, Jean-Ju Chung

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Caroline WiesehöferDepartment of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT, 06510, USA.ORCID 0000-0002-7174-9954
Cameron C GardnerDepartment of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT, 06510, USA.ORCID 0009-0002-9788-3681
Aura StoskusUniversity Clinic Essen, Department of Anatomy, Hufelandstrasse 55, 45147 Essen.
M Agustina BattistoneNephrology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.ORCID 0000-0003-0490-9548
Gunther WennemuthUniversity Clinic Essen, Department of Anatomy, Hufelandstrasse 55, 45147 Essen.ORCID 0000-0003-3313-2475
Jean-Ju ChungDepartment of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT, 06510, USA.ORCID 0000-0001-8018-1355

Funding

CatSper regulation of sperm physiology and fertilityR01HD096745 · NICHD · YALE UNIVERSITY · PI Jean-Ju Lucia Chung · 2019 to 2026
$3.4M
Proton-secreting epithelial cells as key modulators of epididymal mucosal immunity - Administrative SupplementR01HD104672 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI Maria Agustina Battistone · 2021 to 2026
$2.5M
NICHD NIH HHS R01 HD096745NICHD NIH HHS R01 HD104672
6 · The paper itself

Abstract

The intracellular carbonic anhydrase II (CAII) and GPI-anchored extracellular carbonic anhydrase IV (CAIV) are distinctly compartmentalized enzymes that regulate bicarbonate (HCO

Indexed as

BicarbonateCAIICAIVCatSperdigital holographic microscopypHiSLO3spermatozoa

Identifiers

PMID41279408
PMCPMC12632950

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.