Evidence map›Paper›PMID 41279403›Full record

ArticlebioRxiv : the preprint server for biology2025

Co-opting the bacterial lipoprotein pathway in the biosynthesis of a lipidated macrocyclic peptide.

Jeff Y Chen, Lingyang Zhu, Kevin Y Zhang, Deborah A Berthold, Wilfred A van der Donk

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Jeff Y ChenDepartment of Chemistry and Howard Hughes Medical Institute, 600 South Mathews Avenue, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.ORCID 0000-0002-8507-8215
Lingyang ZhuSchool of Chemical Sciences NMR Laboratory, University of Illinois at Urbana-Champaign, Urbana, 61801, IL, USA.ORCID 0000-0002-6657-271X
Kevin Y ZhangDepartment of Chemistry and Howard Hughes Medical Institute, 600 South Mathews Avenue, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.ORCID 0009-0000-3646-2395
Deborah A BertholdDepartment of Chemistry and Howard Hughes Medical Institute, 600 South Mathews Avenue, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.ORCID 0000-0003-3043-5462
Wilfred A van der DonkDepartment of Chemistry and Howard Hughes Medical Institute, 600 South Mathews Avenue, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.ORCID 0000-0002-5467-7071

Funding

Training Program in Chemistry-Interface with BiologyT32GM070421 · NIGMS · UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN · PI HERGENROTHER, PAUL · 2005 to 2019
$5.4M
Posttranslational Modifications during Natural Product BiosynthesisR37GM058822 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI VAN DER DONK, WILFRED A. · 2016 to 2025
$2.9M
4800 Plus MALDI TOF/TOF AnalyzerS10RR027109 · NCRR · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI VAN DER DONK, WILFRED A. · 2010 to 2010
$395k
NCRR NIH HHS S10 RR027109NIGMS NIH HHS R37 GM058822NIGMS NIH HHS T32 GM070421
6 · The paper itself

Abstract

A family of bacterial multinuclear non-heme iron dependent oxidative enzymes (MNIOs) are involved in diverse transformations during the biosynthesis of ribosomally synthesized and post-translationally modified peptides (RiPPs). ChrH from the genus

Indexed as

acylationBacteroidetesbiocatalysisBiochemistryBiosynthesisDUF692LipidsLipopeptidemetalloenzymeNatural ProductsPeptidesRiPPssecondary metabolitesUPF0276

Identifiers

PMID41279403
PMCPMC12636315

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.