Evidence map›Paper›PMID 41279390›Full record

ArticlebioRxiv : the preprint server for biology2025

CRISPR-mediated transcriptional activation as a mutation-independent therapeutic strategy for

Laura Sichlinger, Molly B Reilly, Sakshi Arora, Shuo Zhang, Nicolas Marotta, Kiara L Rodríguez-Acevedo, Marisol Hooks, Kyle S Czarnecki, Julia J Winter, Elisa A Waxman and 10 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Laura SichlingerEpigenetics Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania 19104, USA.ORCID 0000-0003-1359-9633
Molly B ReillyEpigenetics Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania 19104, USA.ORCID 0000-0002-7180-7763
Sakshi AroraCenter for Epilepsy and Neurodevelopmental Disorders (ENDD), University of Pennsylvania Perelman School of Medicine and Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.ORCID 0000-0002-4347-480X
Shuo ZhangEpigenetics Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania 19104, USA.
Nicolas MarottaCenter for Epilepsy and Neurodevelopmental Disorders (ENDD), University of Pennsylvania Perelman School of Medicine and Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.ORCID 0000-0003-3119-5368
Kiara L Rodríguez-AcevedoEpigenetics Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania 19104, USA.ORCID 0000-0002-7839-771X
Marisol HooksEpigenetics Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania 19104, USA.ORCID 0000-0003-4155-8775
Kyle S CzarneckiEpigenetics Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania 19104, USA.
Julia J WinterEpigenetics Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania 19104, USA.ORCID 0000-0001-8518-0167
Elisa A WaxmanCenter for Epilepsy and Neurodevelopmental Disorders (ENDD), University of Pennsylvania Perelman School of Medicine and Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.ORCID 0000-0003-4562-7969
Lea V DunganCenter for Epilepsy and Neurodevelopmental Disorders (ENDD), University of Pennsylvania Perelman School of Medicine and Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.ORCID 0009-0005-3679-7589
Ingie HongDepartment of Neuroscience, Kavli Neuroscience Discovery Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0002-7246-9233
Yoichi ArakiDepartment of Neuroscience, Kavli Neuroscience Discovery Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0002-3455-9377
Richard JohnsonDepartment of Neuroscience, Kavli Neuroscience Discovery Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Richard L HuganirDepartment of Neuroscience, Kavli Neuroscience Discovery Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0001-9783-5183
Giulia PavaniCenter for Epilepsy and Neurodevelopmental Disorders (ENDD), University of Pennsylvania Perelman School of Medicine and Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.ORCID 0000-0002-2522-2684
Deborah L FrenchCenter for Epilepsy and Neurodevelopmental Disorders (ENDD), University of Pennsylvania Perelman School of Medicine and Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.ORCID 0000-0002-7535-1716
Beverly L DavidsonCenter for Epilepsy and Neurodevelopmental Disorders (ENDD), University of Pennsylvania Perelman School of Medicine and Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.ORCID 0000-0002-3715-6290
Benjamin L ProsserCenter for Epilepsy and Neurodevelopmental Disorders (ENDD), University of Pennsylvania Perelman School of Medicine and Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.ORCID 0000-0003-3696-9131
Elizabeth A HellerEpigenetics Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania 19104, USA.ORCID 0000-0002-2984-8705

Funding

The Intellectual and Developmental Disabilities Research Center (IDDRC) at CHOP/PennP50HD105354 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI ERIC D MARSH, ROBERT Thomas SCHULTZ · 2021 to 2026
$9.2M
Epigenetic mechanisms of sustained transcription across cocaine abstinenceR01DA052465 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI Elizabeth A Heller · 2021 to 2026
$4.0M
The Dynamic AMPA Receptor Interactome During Plasticity and LearningR37NS036715 · NINDS · JOHNS HOPKINS UNIVERSITY · PI Richard L Huganir · 2022 to 2026
$3.2M
NICHD NIH HHS P50 HD105354NIDA NIH HHS R01 DA052465NINDS NIH HHS R37 NS036715
6 · The paper itself

Abstract

Synaptic Ras GTPase-activating protein (SynGAP) regulates synaptic strength and neuronal signaling, with essential roles in cortical development and synaptic plasticity. Heterozygous loss-of-function variants in

Identifiers

PMID41279390
PMCPMC12636332

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.