ArticlebioRxiv : the preprint server for biology2025
The magnitude and durability of neutralizing antibody responses to human papillomavirus vaccine do not depend on DNA sensing pathways.
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
How human papillomavirus (HPV) vaccines elicit robust and enduring neutralizing antibody (nAb) responses is unknown, yet such information is valuable to vaccinology. In addition to the major capsid protein, L1, the 4-valent HPV vaccine reportedly also contains recombinant L1 DNA. Nucleic acids in vaccines can enhance antibody responses, but whether L1 DNA enhances HPV vaccine antibody responses is understudied. We tested whether 9-valent HPV (9vHPV) vaccine lots contained L1 DNA and if peak or long-term 9vHPV vaccine-elicited nAb responses were dependent on DNA sensors TLR9, AIM2, or cGAS, or STING or MyD88, the adaptors for cGAS and TLR9, respectively. To quantify L1 DNA, we extracted total nucleic acid per 9vHPV dose and applied singleplex quantitative PCR to amplify HPV6/11/16/18/31/33/45/52/58 L1 sequences. Wildtype mice (wt; C57BL/6J) or mice deficient in DNA sensing pathways (TLR9
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