Evidence map›Paper›PMID 41279379›Full record

ArticlebioRxiv : the preprint server for biology2025

Effect of prescribing and deprescribing oxycodone on pain and function in a mouse model of osteoarthritis: impact of polypharmacy and sex on response.

John Mach, Carina L Blaker, Bryony Winters, Yo Otsu, Elizabeth C Clarke, Heather Allore, Brent Vander Wyk, Kevin Winardi, Roderick Peel, Charlie W Gregson and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

John MachLaboratory of Ageing and Pharmacology, Kolling Institute, Faculty of Medicine and Health, University of Sydney and Royal North Shore Hospital, St Leonards, Sydney, New South Wales, Australia.ORCID 0009-0007-4292-9095
Carina L BlakerMurray Maxwell Biomechanics Laboratory, Institute of Bone and Joint Research, Kolling Institute, Faculty of Medicine and Health, University of Sydney and Royal North Shore Hospital, St Leonards, Sydney, New South Wales, Australia.ORCID 0000-0003-2264-6702
Bryony WintersPain Management Research Institute, Kolling Institute, Faculty of Medicine and Health, University of Sydney and Royal North Shore Hospital, St Leonards, Sydney, New South Wales, Australia.ORCID 0000-0002-4973-0771
Yo OtsuPain Management Research Institute, Kolling Institute, Faculty of Medicine and Health, University of Sydney and Royal North Shore Hospital, St Leonards, Sydney, New South Wales, Australia.ORCID 0000-0003-2828-5063
Elizabeth C ClarkeMurray Maxwell Biomechanics Laboratory, Institute of Bone and Joint Research, Kolling Institute, Faculty of Medicine and Health, University of Sydney and Royal North Shore Hospital, St Leonards, Sydney, New South Wales, Australia.ORCID 0000-0003-2500-5222
Heather AlloreDepartment of Internal Medicine, Yale School of Medicine, 300 George Street 7 Floor, New Haven, Connecticut, 06510.ORCID 0000-0001-7685-8175
Brent Vander WykDepartment of Internal Medicine, Yale School of Medicine, 300 George Street 7 Floor, New Haven, Connecticut, 06510.ORCID 0000-0003-3990-3955
Kevin WinardiLaboratory of Ageing and Pharmacology, Kolling Institute, Faculty of Medicine and Health, University of Sydney and Royal North Shore Hospital, St Leonards, Sydney, New South Wales, Australia.ORCID 0009-0007-7787-8208
Roderick PeelLaboratory of Ageing and Pharmacology, Kolling Institute, Faculty of Medicine and Health, University of Sydney and Royal North Shore Hospital, St Leonards, Sydney, New South Wales, Australia.
Charlie W GregsonLaboratory of Ageing and Pharmacology, Kolling Institute, Faculty of Medicine and Health, University of Sydney and Royal North Shore Hospital, St Leonards, Sydney, New South Wales, Australia.
Neda AssarehPain Management Research Institute, Kolling Institute, Faculty of Medicine and Health, University of Sydney and Royal North Shore Hospital, St Leonards, Sydney, New South Wales, Australia.ORCID 0000-0001-8014-0967
Michelle KouriehPain Management Research Institute, Kolling Institute, Faculty of Medicine and Health, University of Sydney and Royal North Shore Hospital, St Leonards, Sydney, New South Wales, Australia.
Sarah N HilmerLaboratory of Ageing and Pharmacology, Kolling Institute, Faculty of Medicine and Health, University of Sydney and Royal North Shore Hospital, St Leonards, Sydney, New South Wales, Australia.ORCID 0000-0002-5970-1501

Funding

Yale Study Support Suite (YES3): Dashboard and Web Portal Software Supporting Research Workflow through integrated, customizable REDCap External ModulesP30AG021342 · NIA · YALE UNIVERSITY · PI Lauren Ferrante · 2002 to 2026
$37.9M
Yale Alzheimer Disease Research CenterP30AG066508 · NIA · YALE UNIVERSITY · PI STEPHEN M STRITTMATTER · 2020 to 2026
$30.2M
NIA NIH HHS P30 AG021342NIA NIH HHS P30 AG066508
6 · The paper itself

Abstract

Osteoarthritis and polypharmacy are common in older adults. While not consistent with guidelines, opioid analgesia is commonly prescribed to older adults with osteoarthritis and other causes of chronic non-cancer pain. Long term use of opioids is associated with tolerance, addiction, loss of efficacy and adverse events. Thus, deprescribing (reducing or ceasing) opioids is often required. The effect of polypharmacy on the efficacy and safety of opioid prescribing and deprescribing in this setting is poorly understood. Here we aimed to assess the effects of chronic oxycodone, as monotherapy and in polypharmacy (oxycodone, citalopram, simvastatin, oxybutynin, and metoprolol), and of deprescribing oxycodone, on allodynia, physical and cognitive function, and daily activities in middle-aged, osteoarthritic male and female C57BL/6J mice (n=11-15/ group). Only oxycodone monotherapy reduced mechanical allodynia after 6 weeks of treatment. Chronic polypharmacy with oxycodone transiently increased mechanical allodynia in the injured limb and caused marked reductions in mobility, maximum walking speed, activities of daily living, and increased anxiety. Polypharmacy also altered daily activities detected by an automated animal behaviour recognition cage. Sex differences in treatment response were observed in frailty measurements and activity over 23 hours. Deprescribing oxycodone was well tolerated and did not alter physical or cognitive function but did reverse some of the daily activity changes and mechanical allodynia in polypharmacy treated animals only. This clinically relevant preclinical model provides an opportunity to understand the effects of prescribing and deprescribing opioids in older adults with osteoarthritis, including the impact of comedications and sex.

Indexed as

DeprescribingMedicine safetyOpioidsOsteoarthritisPhysical functionPolypharmacy

Identifiers

PMID41279379
PMCPMC12633284

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.