Evidence map›Paper›PMID 41279377›Full record

ArticlebioRxiv : the preprint server for biology2025

The Unique Efg1 Fungal Virulence Regulon in the Catheterized Bladder Environment.

Alyssa Ann La Bella, Nicholas C Gervais, Kurt N Kohler, Chloe L P Obernuefemann, Ilse D Jacobsen, Rebecca S Shapiro, Michael G Caparon, Scott J Hultgren, Ana Lidia Flores-Mireles, Felipe Hiram Santiago-Tirado

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Alyssa Ann La BellaDepartment of Biological Sciences, University of Notre Dame, Notre Dame, IN, USA.
Nicholas C GervaisDepartment of Molecular and Cellular Biology, University of Guelph, Guelph, ON, Canada.
Kurt N KohlerDepartment of Biological Sciences, University of Notre Dame, Notre Dame, IN, USA.
Chloe L P ObernuefemannDepartment of Molecular Microbiology, Washington University School of Medicine, MO 63110, USA.
Ilse D JacobsenResearch Group Microbial Immunology, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knoell Institute (HKI), Beutenbergstrasse 11a, 07745, Jena, Germany.
Rebecca S ShapiroDepartment of Molecular and Cellular Biology, University of Guelph, Guelph, ON, Canada.
Michael G CaparonDepartment of Molecular Microbiology, Washington University School of Medicine, MO 63110, USA.
Scott J HultgrenDepartment of Molecular Microbiology, Washington University School of Medicine, MO 63110, USA.
Ana Lidia Flores-MirelesDepartment of Biological Sciences, University of Notre Dame, Notre Dame, IN, USA.ORCID 0000-0003-4610-4246
Felipe Hiram Santiago-TiradoDepartment of Biological Sciences, University of Notre Dame, Notre Dame, IN, USA.ORCID 0000-0002-6453-4904

Funding

MOLECULAR BASIS OF E. COLI ADHESINS IN BLADDER DISORDERSR01DK051406 · NIDDK · WASHINGTON UNIVERSITY · PI SCOTT J. HULTGREN · 1997 to 2026
$8.8M
Understanding the role of catheter-associated protein deposition in the development of CAUTIR01DK128805 · NIDDK · UNIVERSITY OF NOTRE DAME · PI FLORES-MIRELES, ANA LIDIA, HOWELL, CAITLIN L · 2021 to 2025
$1.9M
Host and fungal factors important for the cryptococcal intracellular nicheR01AI177875 · NIAID · UNIVERSITY OF NOTRE DAME · PI Felipe H Santiago-Tirado · 2023 to 2026
$1.6M
The role of a pleiotropic drug resistance (PDR) transporter in the cryptococcal-host interactionsR21AI171742 · NIAID · UNIVERSITY OF NOTRE DAME · PI SANTIAGO-TIRADO, FELIPE H · 2023 to 2024
$430k
NIAID NIH HHS R01 AI177875NIAID NIH HHS R21 AI171742NIDDK NIH HHS R01 DK051406NIDDK NIH HHS R01 DK128805
6 · The paper itself

Abstract

Urinary catheterization, a common procedure in hospitals and nursing home facilities, is a primary driver of hospital-acquired infections (HAI). These devices frequently lead to catheter-associated urinary tract infections (CAUTIs), which often progress to severe complication, sepsis, and ultimately death. The fungus

Identifiers

PMID41279377
PMCPMC12637609

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.