Evidence map›Paper›PMID 41279373›Full record

ArticlebioRxiv : the preprint server for biology2025

Axonemal dynein contributions to flagellar beat types and waveforms.

Sophia Fochler, Matthew H Doran, Tom Beneke, James Smith, Cecile Fort, Benjamin J Walker, Alan Brown, Eva Gluenz, Richard J Wheeler

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sophia FochlerInstitute of Cell Biology, University of Bern, Bern, Switzerland.ORCID 0009-0002-4508-1951
Matthew H DoranDepartment of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-5224-4133
Tom BenekeSir William Dunn School of Pathology, University of Oxford, Oxford, UK.ORCID 0000-0001-9117-2649
James SmithSir William Dunn School of Pathology, University of Oxford, Oxford, UK.
Cecile FortMedawar Building for Pathogen Research, Nuffield Department of Medicine, University of Oxford, Oxford, UK.ORCID 0000-0003-3248-3505
Benjamin J WalkerDepartment of Mathematics, University College London, London, UK.
Alan BrownDepartment of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-0021-0476
Eva GluenzInstitute of Cell Biology, University of Bern, Bern, Switzerland.ORCID 0000-0003-4346-8896
Richard J WheelerMedawar Building for Pathogen Research, Nuffield Department of Medicine, University of Oxford, Oxford, UK.ORCID 0000-0002-4270-8360

Funding

Mechanoregulation of Ciliary MotilityR01GM141109 · NIGMS · HARVARD MEDICAL SCHOOL · PI BROWN, ALAN · 2021 to 2025
$2.1M
Structural characterization of single, double and triple-headed axonemal dyneinsR01GM143183 · NIGMS · HARVARD MEDICAL SCHOOL · PI BROWN, ALAN · 2022 to 2025
$1.4M
NIGMS NIH HHS R01 GM141109NIGMS NIH HHS R01 GM143183Wellcome Trust
6 · The paper itself

Abstract

Eukaryotic flagella, or motile cilia, are iconic molecular machines whose beating drives cell propulsion and fluid transport across diverse organisms. Beat type and waveform are tailored to function, differing between species and cell types, and individual flagella can switch between beat types. Aberrant beating causes ciliopathies and infertility in humans

Identifiers

PMID41279373
PMCPMC12637542

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.