Evidence map›Paper›PMID 41279363›Full record

ArticlebioRxiv : the preprint server for biology2025

Modulating inter-mitochondrial contacts to increase membrane potential for mitigating blue light damage.

Yuxin Wang, Kangqiang Qiu, Weiwei Zou, Prativa Amom, Tushar H Ganjawala, Eugene Lee, Zhiqi Tian, Xiuqiong Xu, Taosheng Huang, Nien-Pei Tsai and 6 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Yuxin WangDepartment of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
Kangqiang QiuDepartment of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
Weiwei ZouDivision of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Prativa AmomDivisions of Developmental Biology and Neonatology and Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Tushar H GanjawalaDivisions of Developmental Biology and Neonatology and Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Eugene LeeDepartment of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
Zhiqi TianDepartment of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
Xiuqiong XuDepartment of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
Taosheng HuangDivision of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Nien-Pei TsaiDepartment of Molecular & Integrative Physiology, School of Molecular and Cellular Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
Donglu ShiThe Materials Science and Engineering Program, Department of Mechanical and Materials Engineering, University of Cincinnati, Cincinnati, OH 45221, USA.
Ping KangDepartment of Genetics, Development, and Cell Biology, Iowa State University, Ames, IA 50011, USA.
Hua BaiDepartment of Genetics, Development, and Cell Biology, Iowa State University, Ames, IA 50011, USA.
Amanda L ZachariasDepartment of Pediatrics, University at Buffalo, 1001 Main Street, Buffalo, NY 14203, USA.ORCID 0000-0002-4818-916X
Kai ZhangDepartment of Biochemistry, School of Molecular and Cellular Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
Jiajie DiaoDepartment of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.ORCID 0000-0003-4288-3203

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
The crosstalk of organelles involved in autophagosome biogenesisR35GM128837 · NIGMS · UNIVERSITY OF CINCINNATI · PI Jiajie Diao · 2018 to 2026
$3.3M
Mechanism of Gp1 mGluR-dependent translation and plasticityR01MH124827 · NIMH · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI TSAI, NIEN-PEI, ZHANG, KAI · 2021 to 2025
$2.3M
Autonomous and Non-Autonomous Regulation of Cardiac AgingR01AG058741 · NIA · IOWA STATE UNIVERSITY · PI BAI, HUA · 2019 to 2023
$1.5M
Precise regulation of native transcription factor at the single-cell levelR01GM132438 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI ZHANG, KAI · 2019 to 2022
$1.4M
Role of peroxisome-mitochondrion communication in tissue agingR01AG075156 · NIA · IOWA STATE UNIVERSITY · PI Hua Bai · 2023 to 2026
$1.2M
NIA NIH HHS R01 AG058741NIA NIH HHS R01 AG075156NIGMS NIH HHS R01 GM132438NIGMS NIH HHS R35 GM128837NIH HHS P40 OD010440NIMH NIH HHS R01 MH124827
6 · The paper itself

Abstract

Mitochondrial membrane potential (MMP) is essential for mitochondrial functions, yet current methods for modulating MMP lack precise spatial and temporal control. Here, we present an optogenetic system that enables reversible formation of inter-mitochondrial contacts (mito-contacts) with high spatiotemporal precision. Blue light stimulation induces rapid formation of mito-contacts, which fully dissipate upon cessation of illumination. These light-induced mito-contacts can enhance MMP, leading to increased ATP production under stress conditions. Moreover, in human retinal cells and

Indexed as

membrane contact sitesmitochondriaoptogenetics

Identifiers

PMID41279363
PMCPMC12633366

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.