Evidence map›Paper›PMID 41279355›Full record

ArticlebioRxiv : the preprint server for biology2025

Cross-Species Morphology Learning Enables Nucleic Acid-Independent Detection of Live Mutant Blood Cells.

Sarmad Ahmad Khan, Dominik Faerber, Danielle Kirkey, Simon Raffel, Brandon Hadland, Michael Deininger, Florian Buettner, Helong Gary Zhao

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sarmad Ahmad KhanGerman Cancer Research Center (DKFZ), Heidelberg, Germany.
Dominik FaerberDepartment of Information Technology and Electrical Engineering, ETH Zurich, Zurich, Switzerland.
Danielle KirkeyTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, USA.
Simon RaffelDepartment of Medicine, Hematology, Oncology and Rheumatology, University Hospital Heidelberg, Heidelberg, Germany.
Brandon HadlandTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, USA.
Michael DeiningerVersiti Blood Research Institute, Milwaukee, USA.
Florian BuettnerGerman Cancer Research Center (DKFZ), Heidelberg, Germany.
Helong Gary ZhaoGerman Cancer Research Center (DKFZ), Heidelberg, Germany.

Funding

Dormancy-dependent determination of hematopoietic stem cell fate from hemogenic endotheliumR01HL168110 · NHLBI · FRED HUTCHINSON CANCER CENTER · PI Brandon K Hadland · 2023 to 2026
$1.8M
NHLBI NIH HHS R01 HL168110
6 · The paper itself

Abstract

In hematology/oncology clinics, molecular diagnostics based on nucleic acid sequencing or hybridization are routinely employed to detect malignancy-associated genetic mutations and are instrumental in therapeutic stratification and prognostication. However, their limited cost-efficiency constrains their use in pre-malignant screening-specifically, the detection of rare circulating mutant blood cells in asymptomatic individuals. In both neonates and adults, the presence of malignancy-associated mutations in peripheral blood correlates with an elevated risk of future neoplastic transformation, with certain mutations, such as

Identifiers

PMID41279355
PMCPMC12633555

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.