Evidence map›Paper›PMID 41279353›Full record

ArticlebioRxiv : the preprint server for biology2025

Apoptosis promotes fertility in

U N Saydee-Onwubiko, M E Werner, G C Trapp, A S Maddox

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

U N Saydee-OnwubikoDepartment of Biology, University of North Carolina, Chapel Hill, NC 27599.
M E WernerDepartment of Biology, University of North Carolina, Chapel Hill, NC 27599.
G C TrappDepartment of Biology, University of North Carolina, Chapel Hill, NC 27599.
A S MaddoxDepartment of Biology, University of North Carolina, Chapel Hill, NC 27599.

Funding

Mechanisms of cell shape change in cytokinesisR35GM144238 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Amy Shaub Maddox · 2022 to 2026
$2.4M
Defining the contributions of apoptosis to germline syncytium function during oogenesisF32HD117621 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Udodirim Onwubiko · 2025 to 2026
$155k
NICHD NIH HHS F32 HD117621NIGMS NIH HHS R35 GM144238
6 · The paper itself

Abstract

Programmed cell death (apoptosis) during oogenesis is conserved across metazoans and linked to regulation of oocyte number and quality. In oogenic germlines, the removal of developing oocytes by apoptosis ensures that oocytes do not contain DNA damage or multiple nuclei. Beyond this chromatin-quality control assurance role, it was unknown how apoptosis contributes to oocyte quality. We used the nematode

Indexed as

ApoptosisC. elegansGermline architectureInfertilityOogenesis

Identifiers

PMID41279353
PMCPMC12633224

What OpenQuestion holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.